CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2

•Abiraterone, a CYP17A1 inhibitor also targets CYP21A2.•Effect of abiraterone on steroid metabolism was studied in cultured cells.•Abiraterone inhibited CYP21A2 activity in cell and recombinant protein assays.•Abiraterone may cause lower cortisol levels. Abiraterone is an inhibitor of CYP17A1 which...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2017-11, Vol.174, p.192-200
Hauptverfasser:	Malikova, Jana, Brixius-Anderko, Simone, Udhane, Sameer S., Parween, Shaheena, Dick, Bernhard, Bernhardt, Rita, Pandey, Amit V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abiraterone Androgens Androstenes - pharmacology Antineoplastic Agents - pharmacology Castration Cell Line, Tumor Chromatography Computer applications CYP17A1 CYP1A2 protein CYP21A2 CYP2D6 protein Cytochrome P450 Drugs Enzymes Escherichia coli - genetics Gas chromatography Humans Hydrocortisone Hydroxylase Male Mass spectroscopy Molecular Docking Simulation Oncology Prostate cancer Prostatic Neoplasms Steroid 17-alpha-Hydroxylase - antagonists & inhibitors Steroid 21-Hydroxylase - antagonists & inhibitors Steroid 21-Hydroxylase - chemistry Steroid 21-Hydroxylase - genetics Steroid 21-Hydroxylase - metabolism Steroidogenesis Steroids - metabolism
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