Tryptophan circuit in fatigue: From blood to brain and cognition

•Central fatigue is triggered by synergetic effect of peripheral tryptophan and kynurenine.•The tryptophan-kynurenine pathway activates in glial-neuronal interactions in central fatigue with cognitive dysfunction.•Fatigue cognitive circuit includes the tryptophan-kynurenine pathway in the central-pe...

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Veröffentlicht in:	Brain research 2017-11, Vol.1675, p.116-126
Hauptverfasser:	Yamashita, Masatoshi, Yamamoto, Takanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Brain - metabolism Central-peripheral linkage Cognition Cognition - physiology Fatigue - blood Fatigue - metabolism Fatigue cognitive circuit Female Glial-neuronal interaction Kynurenine - blood Kynurenine - metabolism Maze Learning - physiology Rats Rats, Sprague-Dawley Rats, Wistar Tryptophan Tryptophan - blood Tryptophan - metabolism
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