Domain Swapping in p13suc1 Results in Formation of Native-like, Cytotoxic Aggregates

The field of protein aggregation has been occupied mainly with the study of β-strand self-association that occurs as a result of misfolding and leads to the formation of toxic protein aggregates and amyloid fibers. However, some of these aggregates retain native-like structural and enzymatic propert...

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Veröffentlicht in:Journal of molecular biology 2006-10, Vol.363 (2), p.496-505
Hauptverfasser: Rousseau, Frederic, Wilkinson, Hannah, Villanueva, Josep, Serrano, Luis, Schymkowitz, Joost W.H., Itzhaki, Laura S.
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Sprache:eng
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