Tamoxifen for the Prevention of Breast Cancer: Current Status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

Background: Initial findings from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (P-1) demonstrated that tamoxifen reduced the risk of estrogen receptor–positive tumors and osteoporotic fractures in women at increased risk for breast cancer. Side effects of va...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2005-11, Vol.97 (22), p.1652-1662
Hauptverfasser:	Fisher, Bernard, Costantino, Joseph P., Wickerham, D. Lawrence, Cecchini, Reena S., Cronin, Walter M., Robidoux, Andre, Bevers, Therese B., Kavanah, Maureen T., Atkins, James N., Margolese, Richard G., Runowicz, Carolyn D., James, Joan M., Ford, Leslie G., Wolmark, Norman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Agents, Hormonal - therapeutic use Bias Biological and medical sciences Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - prevention & control Chemotherapy Clinical trials Confidence Intervals Drug therapy Endometrial Neoplasms - chemically induced Estrogen Receptor Modulators - adverse effects Estrogen Receptor Modulators - therapeutic use Female Follow-Up Studies Fractures, Bone - etiology Fractures, Bone - prevention & control Humans Incidence Medical sciences Middle Aged Odds Ratio Osteoporosis - complications Patient Selection Pharmacology. Drug treatments Receptors, Estrogen - analysis Research Design Risk Assessment Risk Factors Side effects Stroke - etiology Tamoxifen - adverse effects Tamoxifen - therapeutic use Thromboembolism - chemically induced Thromboembolism - complications Time Factors Tumors
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