Protein Catenation Enhances Both the Stability and Activity of Folded Structural Domains

Catenanes are intriguing molecular architectures with unique properties. Herein, we report the cellular synthesis of protein catenanes containing folded structural domains, aided by synergy between p53 dimerization and SpyTag/SpyCatcher chemistry. Concatenation of green fluorescent protein (GFP) was...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2017-11, Vol.56 (45), p.13985-13989
Hauptverfasser:	Wang, Xiao‐Wei, Zhang, Wen‐Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catalytic activity Catenation Cellular structure Chemical synthesis Dihydrofolate reductase Dimerization Fluorescence Green fluorescent protein p53 Protein Properties (attributes) Protein biosynthesis protein engineering protein stability Proteins Proteolysis SpyCatcher/SpyTag Structural stability Topology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!