Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma

Airway hyperresponsiveness is a major feature of asthma attributed predominantly to an extrinsic immune/inflammatory response increasing airway smooth muscle (ASM) contractility. We investigated whether increased ASM expression of orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2018-07, Vol.142 (1), p.207-218.e6
Hauptverfasser:	Chen, Jun, Miller, Marina, Unno, Hirotoshi, Rosenthal, Peter, Sanderson, Michael J., Broide, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperresponsiveness airway smooth muscle asthma ORMDL3 sarcoplasmic reticulum Ca2+ transport ATPase 2b
Online-Zugang:	Volltext
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