Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

The liver is the only organ in mammals that fully regenerates even after major injury. To identify orchestrators of this regenerative response, we performed quantitative large-scale proteomics analysis of cytoplasmic and nuclear fractions from normal versus regenerating mouse liver. Proteins of the...

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Veröffentlicht in:	Developmental cell 2017-09, Vol.42 (6), p.616-625.e8
Hauptverfasser:	Bachofner, Marc, Speicher, Tobias, Bogorad, Roman L., Muzumdar, Sukalp, Derrer, Carina P., Hürlimann, Fabrizio, Böhm, Friederike, Nanni, Paolo, Kockmann, Tobias, Kachaylo, Ekaterina, Meyer, Michael, Padrissa-Altés, Susagna, Graf, Rolf, Anderson, Daniel G., Koteliansky, Victor, auf dem Keller, Ulrich, Werner, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals EGF Endocytosis - drug effects Endosomal Sorting Complexes Required for Transport - metabolism Eps15 Gene Knockdown Techniques hepatocyte Hepatocytes - drug effects Hepatocytes - metabolism HGF Liver - drug effects Liver - injuries Liver - metabolism Liver - pathology liver regeneration Liver Regeneration - drug effects Male Mice, Inbred C57BL Mitogens - pharmacology Nedd4 Ubiquitin Protein Ligases Nedd4-1 Polyubiquitin - metabolism Proteome - metabolism proteomics Proteomics - methods Receptor, Epidermal Growth Factor - metabolism Reproducibility of Results RNA, Small Interfering - metabolism Signal Transduction - drug effects siRNA ubiquitin Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects
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