miR-155 targets Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) affecting millions of people worldwide. miR-155 has been reported to be upregulated in various inflammatory diseases and is a positive regulator of the T-cell response. IL-17 secreting helper T (Th17) cells have been heavily impli...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2017-10, Vol.213 (10), p.1289-1295
Hauptverfasser:	Hou, Jiangtao, Hu, Xueying, Chen, Bin, Chen, Xu, Zhao, Lina, Chen, Zhuoqun, Liu, Fengbin, Liu, Zhihui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - immunology Colon - metabolism Colon - pathology Dextran Sulfate Disease Models, Animal Female Inflammatory bowel disease Interleukin-17 - blood Interleukin-17 - metabolism Interleukin-23 - blood Interleukin-23 - metabolism Interleukin-6 - blood Interleukin-6 - metabolism Mice, Inbred BALB C MicroRNAs - genetics MicroRNAs - metabolism miR-155 Signal Transduction Th17 Cells - immunology Th17 Cells - metabolism Time Factors Ulcerative colitis
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