Prognostic role of progesterone receptor expression in a population-based analysis
Purpose The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis. Materials and methods Through the Tuscan C...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2017-12, Vol.143 (12), p.2505-2509 |
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| creator | Caldarella, Adele Barchielli, Alessandro |
| description | Purpose
The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis.
Materials and methods
Through the Tuscan Cancer Registry data on all the invasive breast cancer cases diagnosed during the period 2004–2005 in the provinces of Florence and Prato, central Italy, were retrieved. Histological reports were re-examined to obtain information on the percentage of positive tumor cells for estrogen (ER), progesterone (PR) receptors, Ki67 marker and human epidermal growth factor 2 (HER2). Information on age, stage, differentiation grade were also obtained.
Results
Out of 1487 patients, 28% had PR− breast cancer. These patients were older (p 0.006) than PR+ cancer patients, with more frequently high Ki67 (
p
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| doi_str_mv | 10.1007/s00432-017-2514-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1937755988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1965553043</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-ca5df73fd140c13d7d18cf57a15edf69d57ab40d41c0a1674b12be198ed960a33</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7vrxA7xIwIuXaqZpmvYoi1-woIieQ5pMly7dpiYt6L83ZVcRwVMyM8-88_IScgbsChiT14GxjKcJA5mkArKE75E5TB3gXOyTeRxAIlLIZ-QohDWLtZDpIZmlRVGUUJRz8vLs3apzYWgM9a5F6mraxxaGAb3rkHo02A_OU_zoPYbQuI42HdW0d_3Y6iHWSaUDWqo73X6GJpyQg1q3AU937zF5u7t9XTwky6f7x8XNMjFcpkNitLC15LWFjBngVlooTC2kBoG2zksbv1XGbAaGachlVkFaIZQF2jJnmvNjcrnVjX7fx2hYbZpgsG11h24MCkoupRBlUUT04g-6dqOPficqF0LwGGSkYEsZ70LwWKveNxvtPxUwNQWutoGrmKOaAlfTzvlOeaw2aH82vhOOQLoFQhx1K_S_Tv-r-gXRaIvU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1965553043</pqid></control><display><type>article</type><title>Prognostic role of progesterone receptor expression in a population-based analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Caldarella, Adele ; Barchielli, Alessandro</creator><creatorcontrib>Caldarella, Adele ; Barchielli, Alessandro</creatorcontrib><description>Purpose
The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis.
Materials and methods
Through the Tuscan Cancer Registry data on all the invasive breast cancer cases diagnosed during the period 2004–2005 in the provinces of Florence and Prato, central Italy, were retrieved. Histological reports were re-examined to obtain information on the percentage of positive tumor cells for estrogen (ER), progesterone (PR) receptors, Ki67 marker and human epidermal growth factor 2 (HER2). Information on age, stage, differentiation grade were also obtained.
Results
Out of 1487 patients, 28% had PR− breast cancer. These patients were older (p 0.006) than PR+ cancer patients, with more frequently high Ki67 (
p
< 0.0001), HER2 + (
p
< 0.0001), ER− (
p
< 0.0001) tumoral expression. The ER+/PR+ subtype was the most represented (n.1053), while ER−/PR+ was the most rare (n.23); 210 cases (14.1%) ER+ PR− and 201 (13.5%) ER−/PR− cases were found. Analysis of survival by the Cox proportional hazards model showed an independent prognostic value of PR expression (
p
< 0.0001), also when estrogen, Ki67, HER2 status and age were included. The 5-year cancer-specific survival was 82.1, 86.5, 100, 92% for ER−/PR−, ER+/PR−, ER−/PR+, ER+/PR+ subtype, respectively.
Conclusions
Our study revealed significant differences in clinicopathological characteristics among breast cancer according to PR expression and confirmed its prognostic independent role, suggesting a role of PR in the improvement of breast cancer prognostic characterization.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-017-2514-3</identifier><identifier>PMID: 28889189</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer Research ; Epidermal growth factor ; ErbB-2 protein ; Estrogen receptors ; Estrogens ; Female ; Health risk assessment ; Hematology ; Humans ; Immunohistochemistry ; Internal Medicine ; Invasiveness ; Italy - epidemiology ; Kaplan-Meier Estimate ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Oncology ; Original Article – Cancer Research ; Progesterone ; Prognosis ; Receptor, ErbB-2 - biosynthesis ; Receptors, Estrogen - biosynthesis ; Receptors, Progesterone - biosynthesis ; Tumor cells</subject><ispartof>Journal of cancer research and clinical oncology, 2017-12, Vol.143 (12), p.2505-2509</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ca5df73fd140c13d7d18cf57a15edf69d57ab40d41c0a1674b12be198ed960a33</citedby><cites>FETCH-LOGICAL-c372t-ca5df73fd140c13d7d18cf57a15edf69d57ab40d41c0a1674b12be198ed960a33</cites><orcidid>0000-0001-8731-8617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-017-2514-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-017-2514-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28889189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caldarella, Adele</creatorcontrib><creatorcontrib>Barchielli, Alessandro</creatorcontrib><title>Prognostic role of progesterone receptor expression in a population-based analysis</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis.
Materials and methods
Through the Tuscan Cancer Registry data on all the invasive breast cancer cases diagnosed during the period 2004–2005 in the provinces of Florence and Prato, central Italy, were retrieved. Histological reports were re-examined to obtain information on the percentage of positive tumor cells for estrogen (ER), progesterone (PR) receptors, Ki67 marker and human epidermal growth factor 2 (HER2). Information on age, stage, differentiation grade were also obtained.
Results
Out of 1487 patients, 28% had PR− breast cancer. These patients were older (p 0.006) than PR+ cancer patients, with more frequently high Ki67 (
p
< 0.0001), HER2 + (
p
< 0.0001), ER− (
p
< 0.0001) tumoral expression. The ER+/PR+ subtype was the most represented (n.1053), while ER−/PR+ was the most rare (n.23); 210 cases (14.1%) ER+ PR− and 201 (13.5%) ER−/PR− cases were found. Analysis of survival by the Cox proportional hazards model showed an independent prognostic value of PR expression (
p
< 0.0001), also when estrogen, Ki67, HER2 status and age were included. The 5-year cancer-specific survival was 82.1, 86.5, 100, 92% for ER−/PR−, ER+/PR−, ER−/PR+, ER+/PR+ subtype, respectively.
Conclusions
Our study revealed significant differences in clinicopathological characteristics among breast cancer according to PR expression and confirmed its prognostic independent role, suggesting a role of PR in the improvement of breast cancer prognostic characterization.</description><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Epidermal growth factor</subject><subject>ErbB-2 protein</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Invasiveness</subject><subject>Italy - epidemiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology</subject><subject>Original Article – Cancer Research</subject><subject>Progesterone</subject><subject>Prognosis</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Receptors, Estrogen - biosynthesis</subject><subject>Receptors, Progesterone - biosynthesis</subject><subject>Tumor cells</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1LxDAQhoMo7vrxA7xIwIuXaqZpmvYoi1-woIieQ5pMly7dpiYt6L83ZVcRwVMyM8-88_IScgbsChiT14GxjKcJA5mkArKE75E5TB3gXOyTeRxAIlLIZ-QohDWLtZDpIZmlRVGUUJRz8vLs3apzYWgM9a5F6mraxxaGAb3rkHo02A_OU_zoPYbQuI42HdW0d_3Y6iHWSaUDWqo73X6GJpyQg1q3AU937zF5u7t9XTwky6f7x8XNMjFcpkNitLC15LWFjBngVlooTC2kBoG2zksbv1XGbAaGachlVkFaIZQF2jJnmvNjcrnVjX7fx2hYbZpgsG11h24MCkoupRBlUUT04g-6dqOPficqF0LwGGSkYEsZ70LwWKveNxvtPxUwNQWutoGrmKOaAlfTzvlOeaw2aH82vhOOQLoFQhx1K_S_Tv-r-gXRaIvU</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Caldarella, Adele</creator><creator>Barchielli, Alessandro</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8731-8617</orcidid></search><sort><creationdate>20171201</creationdate><title>Prognostic role of progesterone receptor expression in a population-based analysis</title><author>Caldarella, Adele ; Barchielli, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ca5df73fd140c13d7d18cf57a15edf69d57ab40d41c0a1674b12be198ed960a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Epidermal growth factor</topic><topic>ErbB-2 protein</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Invasiveness</topic><topic>Italy - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Original Article – Cancer Research</topic><topic>Progesterone</topic><topic>Prognosis</topic><topic>Receptor, ErbB-2 - biosynthesis</topic><topic>Receptors, Estrogen - biosynthesis</topic><topic>Receptors, Progesterone - biosynthesis</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caldarella, Adele</creatorcontrib><creatorcontrib>Barchielli, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caldarella, Adele</au><au>Barchielli, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic role of progesterone receptor expression in a population-based analysis</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>143</volume><issue>12</issue><spage>2505</spage><epage>2509</epage><pages>2505-2509</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
The role of progesterone (PR) expression in the management of breast cancer is controversial. The aim of this study is to evaluate the characteristics and prognosis of progesterone status among breast cancers patients in a population-based analysis.
Materials and methods
Through the Tuscan Cancer Registry data on all the invasive breast cancer cases diagnosed during the period 2004–2005 in the provinces of Florence and Prato, central Italy, were retrieved. Histological reports were re-examined to obtain information on the percentage of positive tumor cells for estrogen (ER), progesterone (PR) receptors, Ki67 marker and human epidermal growth factor 2 (HER2). Information on age, stage, differentiation grade were also obtained.
Results
Out of 1487 patients, 28% had PR− breast cancer. These patients were older (p 0.006) than PR+ cancer patients, with more frequently high Ki67 (
p
< 0.0001), HER2 + (
p
< 0.0001), ER− (
p
< 0.0001) tumoral expression. The ER+/PR+ subtype was the most represented (n.1053), while ER−/PR+ was the most rare (n.23); 210 cases (14.1%) ER+ PR− and 201 (13.5%) ER−/PR− cases were found. Analysis of survival by the Cox proportional hazards model showed an independent prognostic value of PR expression (
p
< 0.0001), also when estrogen, Ki67, HER2 status and age were included. The 5-year cancer-specific survival was 82.1, 86.5, 100, 92% for ER−/PR−, ER+/PR−, ER−/PR+, ER+/PR+ subtype, respectively.
Conclusions
Our study revealed significant differences in clinicopathological characteristics among breast cancer according to PR expression and confirmed its prognostic independent role, suggesting a role of PR in the improvement of breast cancer prognostic characterization.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28889189</pmid><doi>10.1007/s00432-017-2514-3</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8731-8617</orcidid></addata></record> |
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| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2017-12, Vol.143 (12), p.2505-2509 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Epidermal growth factor ErbB-2 protein Estrogen receptors Estrogens Female Health risk assessment Hematology Humans Immunohistochemistry Internal Medicine Invasiveness Italy - epidemiology Kaplan-Meier Estimate Medical prognosis Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Oncology Original Article – Cancer Research Progesterone Prognosis Receptor, ErbB-2 - biosynthesis Receptors, Estrogen - biosynthesis Receptors, Progesterone - biosynthesis Tumor cells |
| title | Prognostic role of progesterone receptor expression in a population-based analysis |
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