Functional Analysis of RNA Binding by the Hepatitis C Virus RNA-dependent RNA Polymerase

Protein-RNA interaction plays a critical role in regulating RNA synthesis by the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp). RNAs of 7 nucleotides (nt) or longer had affinities 5-fold better than an RNA of 5 nt, suggesting a minimal length required for binding. To identify RNA conta...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (45), p.38011-38019
Hauptverfasser:	Kim, Young-Chan, Russell, William K., Ranjith-Kumar, C.T., Thomson, Michael, Russell, David H., Kao, C. Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Base Sequence Hepacivirus - enzymology Hepatitis C virus Mutation Protein Binding Protein Conformation RNA, Viral - biosynthesis RNA, Viral - genetics RNA, Viral - metabolism RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism Transcription, Genetic Viral Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!