Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure

Long‐term use of methamphetamine (MA) causes a broad range of cognitive deficits. Recently, it has been reported insulin signaling and mitochondrial biogenesis are involved in cognitive processes. This study aimed to examine whether MA induces cognitive deficits concomitant with insulin signaling im...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular biochemistry 2018-02, Vol.119 (2), p.2345-2355
Hauptverfasser:	Beirami, Elmira, Oryan, Shahrbanoo, Seyedhosseini Tamijani, Seyedeh Masoumeh, Ahmadiani, Abolhassan, Dargahi, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Abnormalities Administration, Intranasal AKT protein Amphetamine-Related Disorders - complications Amphetamine-Related Disorders - genetics Amphetamine-Related Disorders - metabolism Animals Biosynthesis cognition Cognition Disorders - chemically induced Cognition Disorders - drug therapy Cognition Disorders - genetics Cognition Disorders - metabolism Cognitive ability Disease Models, Animal Exposure Gene Expression Regulation - drug effects Gene Regulatory Networks - drug effects Glucose Growth hormones Impairment Insulin Insulin - administration & dosage Insulin - pharmacology insulin signaling Male Memory, Short-Term - drug effects Methamphetamine Methamphetamine - toxicity Mitochondria Mitochondria - drug effects mitochondrial biogenesis Object recognition Pattern recognition Rats Rats, Wistar Signal transduction Signal Transduction - drug effects Signaling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!