Indices of anti‐dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase
ABSTRACT Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody‐dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of...
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| Veröffentlicht in: | Microbiology and immunology 2017-10, Vol.61 (10), p.433-441 |
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| creator | Posadas‐Mondragón, Araceli Aguilar‐Faisal, José Leopoldo Chávez‐Negrete, Adolfo Guillén‐Salomón, Edith Alcántara‐Farfán, Verónica Luna‐Rojas, Lucero Ávila‐Trejo, Amanda Marineth del Carmen Pacheco‐Yépez, Judith |
| description | ABSTRACT
Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody‐dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti‐dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti‐dengue IgM and IgG determined by capture ELISA. Anti‐dengue IgG subclasses were detected by indirect ELISA. Anti‐dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF. |
| doi_str_mv | 10.1111/1348-0421.12536 |
| format | Article |
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Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody‐dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti‐dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti‐dengue IgM and IgG determined by capture ELISA. Anti‐dengue IgG subclasses were detected by indirect ELISA. Anti‐dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12536</identifier><identifier>PMID: 28881485</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Adult ; Antibodies, Viral - blood ; antibody‐dependent enhancement ; Dengue - immunology ; Dengue - virology ; Dengue fever ; Dengue hemorrhagic fever ; Dengue Virus - classification ; Dengue Virus - immunology ; Dengue Virus - isolation & purification ; Dengue Virus - pathogenicity ; Enzyme-linked immunosorbent assay ; Fc receptors ; Female ; Health risks ; Humans ; IgG subclasses ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunoglobulin M ; Immunoglobulin M - blood ; Immunoglobulin M - pharmacology ; Infections ; Lymphocytes - virology ; Male ; Mexico ; Middle Aged ; Monocytes - immunology ; Monocytes - virology ; Neutrophils - immunology ; Neutrophils - virology ; RNA, Viral - analysis ; Secondary infection ; Serotyping ; Severe Dengue - immunology ; Severe Dengue - virology ; Severity of Illness Index ; Vector-borne diseases ; Vitamin E ; Young Adult</subject><ispartof>Microbiology and immunology, 2017-10, Vol.61 (10), p.433-441</ispartof><rights>2017 The Societies and John Wiley & Sons Australia, Ltd</rights><rights>2017 The Societies and John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4366-f2b4103b2b5f7f7390b79bd559ca9a1e396ff3bc1d2ed25e2d7dea54a56af9ee3</citedby><cites>FETCH-LOGICAL-c4366-f2b4103b2b5f7f7390b79bd559ca9a1e396ff3bc1d2ed25e2d7dea54a56af9ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12536$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12536$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28881485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Posadas‐Mondragón, Araceli</creatorcontrib><creatorcontrib>Aguilar‐Faisal, José Leopoldo</creatorcontrib><creatorcontrib>Chávez‐Negrete, Adolfo</creatorcontrib><creatorcontrib>Guillén‐Salomón, Edith</creatorcontrib><creatorcontrib>Alcántara‐Farfán, Verónica</creatorcontrib><creatorcontrib>Luna‐Rojas, Lucero</creatorcontrib><creatorcontrib>Ávila‐Trejo, Amanda Marineth</creatorcontrib><creatorcontrib>del Carmen Pacheco‐Yépez, Judith</creatorcontrib><title>Indices of anti‐dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody‐dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti‐dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti‐dengue IgM and IgG determined by capture ELISA. Anti‐dengue IgG subclasses were detected by indirect ELISA. Anti‐dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>antibody‐dependent enhancement</subject><subject>Dengue - immunology</subject><subject>Dengue - virology</subject><subject>Dengue fever</subject><subject>Dengue hemorrhagic fever</subject><subject>Dengue Virus - classification</subject><subject>Dengue Virus - immunology</subject><subject>Dengue Virus - isolation & purification</subject><subject>Dengue Virus - pathogenicity</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fc receptors</subject><subject>Female</subject><subject>Health risks</subject><subject>Humans</subject><subject>IgG subclasses</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - blood</subject><subject>Immunoglobulin M - pharmacology</subject><subject>Infections</subject><subject>Lymphocytes - virology</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Monocytes - immunology</subject><subject>Monocytes - virology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - virology</subject><subject>RNA, Viral - analysis</subject><subject>Secondary infection</subject><subject>Serotyping</subject><subject>Severe Dengue - immunology</subject><subject>Severe Dengue - virology</subject><subject>Severity of Illness Index</subject><subject>Vector-borne diseases</subject><subject>Vitamin E</subject><subject>Young Adult</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1v1DAYgK2Kqj0KMxuyxNIlrT_iJB5RRctJPXWB2fLH64urxDniWKUbCzu_kV-Cj2s7sODFsv34keUHoXeUXNAyLimvu4rUjF5QJnhzhFYvO6_QivBOVKIh5BS9TumeENayrj5Bp6zrOlp3YoV-rqMLFhKePNZxCb9__HIQtxlwGMccp-0wmTyEiG9wysYOOqUCl7V2eVjwBr4HqyPe6SVAXBJ-CEuPPZg5DFCEDvcwTvPc622w-Nkc8dKXU5sXwLteJ3iDjr0eErx9ms_Q1-tPX64-V7d3N-urj7eVrXnTVJ6ZmhJumBG-9S2XxLTSOCGk1VJT4LLxnhtLHQPHBDDXOtCi1qLRXgLwM3R-8O7m6VuGtKgxJAvDoCNMOSkqeSuolEQW9MM_6P2U51heVyhBCBVdvacuD5Sdp5Rm8Go3h1HPj4oStS-k9j3Uvof6W6jceP_kzWYE98I_JymAOAAP5Qsf_-dTm_XmIP4DQPadhQ</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Posadas‐Mondragón, Araceli</creator><creator>Aguilar‐Faisal, José Leopoldo</creator><creator>Chávez‐Negrete, Adolfo</creator><creator>Guillén‐Salomón, Edith</creator><creator>Alcántara‐Farfán, Verónica</creator><creator>Luna‐Rojas, Lucero</creator><creator>Ávila‐Trejo, Amanda Marineth</creator><creator>del Carmen Pacheco‐Yépez, Judith</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Indices of anti‐dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase</title><author>Posadas‐Mondragón, Araceli ; Aguilar‐Faisal, José Leopoldo ; Chávez‐Negrete, Adolfo ; Guillén‐Salomón, Edith ; Alcántara‐Farfán, Verónica ; Luna‐Rojas, Lucero ; Ávila‐Trejo, Amanda Marineth ; del Carmen Pacheco‐Yépez, Judith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4366-f2b4103b2b5f7f7390b79bd559ca9a1e396ff3bc1d2ed25e2d7dea54a56af9ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>antibody‐dependent enhancement</topic><topic>Dengue - immunology</topic><topic>Dengue - virology</topic><topic>Dengue fever</topic><topic>Dengue hemorrhagic fever</topic><topic>Dengue Virus - classification</topic><topic>Dengue Virus - immunology</topic><topic>Dengue Virus - isolation & purification</topic><topic>Dengue Virus - pathogenicity</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Fc receptors</topic><topic>Female</topic><topic>Health risks</topic><topic>Humans</topic><topic>IgG subclasses</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - blood</topic><topic>Immunoglobulin M - pharmacology</topic><topic>Infections</topic><topic>Lymphocytes - virology</topic><topic>Male</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>Monocytes - immunology</topic><topic>Monocytes - virology</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - virology</topic><topic>RNA, Viral - analysis</topic><topic>Secondary infection</topic><topic>Serotyping</topic><topic>Severe Dengue - immunology</topic><topic>Severe Dengue - virology</topic><topic>Severity of Illness Index</topic><topic>Vector-borne diseases</topic><topic>Vitamin E</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Posadas‐Mondragón, Araceli</creatorcontrib><creatorcontrib>Aguilar‐Faisal, José Leopoldo</creatorcontrib><creatorcontrib>Chávez‐Negrete, Adolfo</creatorcontrib><creatorcontrib>Guillén‐Salomón, Edith</creatorcontrib><creatorcontrib>Alcántara‐Farfán, Verónica</creatorcontrib><creatorcontrib>Luna‐Rojas, Lucero</creatorcontrib><creatorcontrib>Ávila‐Trejo, Amanda Marineth</creatorcontrib><creatorcontrib>del Carmen Pacheco‐Yépez, Judith</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Posadas‐Mondragón, Araceli</au><au>Aguilar‐Faisal, José Leopoldo</au><au>Chávez‐Negrete, Adolfo</au><au>Guillén‐Salomón, Edith</au><au>Alcántara‐Farfán, Verónica</au><au>Luna‐Rojas, Lucero</au><au>Ávila‐Trejo, Amanda Marineth</au><au>del Carmen Pacheco‐Yépez, Judith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indices of anti‐dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>61</volume><issue>10</issue><spage>433</spage><epage>441</epage><pages>433-441</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) because of antibody‐dependent enhancement (ADE). IgG subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti‐dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, 129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico were recruited for this study and anti‐dengue IgM and IgG determined by capture ELISA. Anti‐dengue IgG subclasses were detected by indirect ELISA. Anti‐dengue IgG2 and IgG3 subclasses were detected in patients with dengue. IgG1 increased significantly in the sera of patients with both primary and secondary infections and DHF, but was higher in patients with secondary infections. The IgG4 subclass index was significantly higher in the sera of patients with DHF than in that of those with DF, who were in the early and late acute phase of both primary and secondary infection. In conclusion, indices of subclasses IgG1 and IgG4 were higher in patients with DHF.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28881485</pmid><doi>10.1111/1348-0421.12536</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antibodies, Viral - blood antibody‐dependent enhancement Dengue - immunology Dengue - virology Dengue fever Dengue hemorrhagic fever Dengue Virus - classification Dengue Virus - immunology Dengue Virus - isolation & purification Dengue Virus - pathogenicity Enzyme-linked immunosorbent assay Fc receptors Female Health risks Humans IgG subclasses Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - pharmacology Infections Lymphocytes - virology Male Mexico Middle Aged Monocytes - immunology Monocytes - virology Neutrophils - immunology Neutrophils - virology RNA, Viral - analysis Secondary infection Serotyping Severe Dengue - immunology Severe Dengue - virology Severity of Illness Index Vector-borne diseases Vitamin E Young Adult |
| title | Indices of anti‐dengue immunoglobulin G subclasses in adult Mexican patients with febrile and hemorrhagic dengue in the acute phase |
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