Comparison of Localized and Systemic Otitis Media With ANCA-Associated Vasculitis
OBJECTIVE:To investigate differences in immune activity based on the presence of multiple organ involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and whether hearing outcomes are different between patients with AAV localized to the ear and patients w...
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| Veröffentlicht in: | Otology & neurotology 2017-12, Vol.38 (10), p.e506-e510 |
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| container_title | Otology & neurotology |
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| creator | Okada, Masahiro Suemori, Koichiro Takagi, Daiki Teraoka, Masato Yamada, Hiroyuki Hato, Naohito |
| description | OBJECTIVE:To investigate differences in immune activity based on the presence of multiple organ involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and whether hearing outcomes are different between patients with AAV localized to the ear and patients with systemic AAV.
STUDY DESIGN:Retrospective case review.
SETTING:University hospital.
PATIENTS:Twenty patients with otitis media with AAV (OMAAV) who met the criteria proposed by the OMAAV study group in Japan.
MAIN OUTCOME MEASURE(S):Serum levels of C-reactive protein, ANCA titer, soluble interleukin-2 receptor levels, and hearing outcome.
RESULTS:Thirteen patients had disease involvement of organs other than the ear (systemic OMAAV group); involvement was localized to the ear in seven patients (localized OMAAV group). Serum levels of C-reactive protein, ANCA titer, and soluble interleukin-2 receptor were not significantly different between the groups. Hearing levels at diagnosis and in remission were significantly worse in the localized OMAAV group compared with the systemic OMAAV group. Hearing gain was not significantly different between groups.
CONCLUSION:It is suggested that immune activity in patients with AAV localized to the ear is equivalent to activity in patients with systemic AAV. Therefore, we may need treatment for OMAAV equal in intensity to that for systemic AAV. As the hearing level at diagnosis was worse in patients with AAV localized to the ear than in patients with systemic AAV, earlier diagnosis may be needed to improve hearing outcome. |
| doi_str_mv | 10.1097/MAO.0000000000001563 |
| format | Article |
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STUDY DESIGN:Retrospective case review.
SETTING:University hospital.
PATIENTS:Twenty patients with otitis media with AAV (OMAAV) who met the criteria proposed by the OMAAV study group in Japan.
MAIN OUTCOME MEASURE(S):Serum levels of C-reactive protein, ANCA titer, soluble interleukin-2 receptor levels, and hearing outcome.
RESULTS:Thirteen patients had disease involvement of organs other than the ear (systemic OMAAV group); involvement was localized to the ear in seven patients (localized OMAAV group). Serum levels of C-reactive protein, ANCA titer, and soluble interleukin-2 receptor were not significantly different between the groups. Hearing levels at diagnosis and in remission were significantly worse in the localized OMAAV group compared with the systemic OMAAV group. Hearing gain was not significantly different between groups.
CONCLUSION:It is suggested that immune activity in patients with AAV localized to the ear is equivalent to activity in patients with systemic AAV. Therefore, we may need treatment for OMAAV equal in intensity to that for systemic AAV. As the hearing level at diagnosis was worse in patients with AAV localized to the ear than in patients with systemic AAV, earlier diagnosis may be needed to improve hearing outcome.</description><identifier>ISSN: 1531-7129</identifier><identifier>EISSN: 1537-4505</identifier><identifier>DOI: 10.1097/MAO.0000000000001563</identifier><identifier>PMID: 28885482</identifier><language>eng</language><publisher>United States: Copyright by Otology & Neurotology, Inc. Image copyright Wolters Kluwer Health/Anatomical Chart Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications ; Antibodies, Antineutrophil Cytoplasmic - blood ; Audiometry ; C-Reactive Protein - analysis ; Female ; Granulomatosis with Polyangiitis - complications ; Humans ; Interleukin-2 Receptor alpha Subunit - metabolism ; Male ; Middle Aged ; Otitis Media - etiology ; Recovery of Function ; Retrospective Studies</subject><ispartof>Otology & neurotology, 2017-12, Vol.38 (10), p.e506-e510</ispartof><rights>Copyright © 2017 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3563-3cf2c75d34da3bf6595a016e34142037b0905fd435defaeceab82bcb11deac8d3</citedby><cites>FETCH-LOGICAL-c3563-3cf2c75d34da3bf6595a016e34142037b0905fd435defaeceab82bcb11deac8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28885482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Suemori, Koichiro</creatorcontrib><creatorcontrib>Takagi, Daiki</creatorcontrib><creatorcontrib>Teraoka, Masato</creatorcontrib><creatorcontrib>Yamada, Hiroyuki</creatorcontrib><creatorcontrib>Hato, Naohito</creatorcontrib><title>Comparison of Localized and Systemic Otitis Media With ANCA-Associated Vasculitis</title><title>Otology & neurotology</title><addtitle>Otol Neurotol</addtitle><description>OBJECTIVE:To investigate differences in immune activity based on the presence of multiple organ involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and whether hearing outcomes are different between patients with AAV localized to the ear and patients with systemic AAV.
STUDY DESIGN:Retrospective case review.
SETTING:University hospital.
PATIENTS:Twenty patients with otitis media with AAV (OMAAV) who met the criteria proposed by the OMAAV study group in Japan.
MAIN OUTCOME MEASURE(S):Serum levels of C-reactive protein, ANCA titer, soluble interleukin-2 receptor levels, and hearing outcome.
RESULTS:Thirteen patients had disease involvement of organs other than the ear (systemic OMAAV group); involvement was localized to the ear in seven patients (localized OMAAV group). Serum levels of C-reactive protein, ANCA titer, and soluble interleukin-2 receptor were not significantly different between the groups. Hearing levels at diagnosis and in remission were significantly worse in the localized OMAAV group compared with the systemic OMAAV group. Hearing gain was not significantly different between groups.
CONCLUSION:It is suggested that immune activity in patients with AAV localized to the ear is equivalent to activity in patients with systemic AAV. Therefore, we may need treatment for OMAAV equal in intensity to that for systemic AAV. As the hearing level at diagnosis was worse in patients with AAV localized to the ear than in patients with systemic AAV, earlier diagnosis may be needed to improve hearing outcome.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Audiometry</subject><subject>C-Reactive Protein - analysis</subject><subject>Female</subject><subject>Granulomatosis with Polyangiitis - complications</subject><subject>Humans</subject><subject>Interleukin-2 Receptor alpha Subunit - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Otitis Media - etiology</subject><subject>Recovery of Function</subject><subject>Retrospective Studies</subject><issn>1531-7129</issn><issn>1537-4505</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBwh5ySbFjuM4WUYRL6mlQryWlmNPVENSlzhRVb6elBaEWDCbmcW5M6OD0CklY0pScTHNZmPyqyiP2R4aUs5EEHHC979mGggapgN05P1rzwjGxSEahEmS8CgJh-g-d_VSNda7BXYlnjitKvsBBquFwQ9r30JtNZ61trUeT8FYhV9sO8fZXZ4FmfdOW9X2-LPyuqs21DE6KFXl4WTXR-jp6vIxvwkms-vbPJsEmvWfBkyXoRbcsMgoVpQxT7kiNAYW0SgkTBQkJbw0EeMGSgUaVJGEhS4oNaB0YtgInW_3Lhv33oFvZW29hqpSC3CdlzRlgtM0pmGPRltUN877Bkq5bGytmrWkRG5kyl6m_Cuzj53tLnRFDeYn9G2vB5ItsHJVC41_q7oVNHIOqmrn_-_-BC8ggIA</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Okada, Masahiro</creator><creator>Suemori, Koichiro</creator><creator>Takagi, Daiki</creator><creator>Teraoka, Masato</creator><creator>Yamada, Hiroyuki</creator><creator>Hato, Naohito</creator><general>Copyright by Otology & Neurotology, Inc. Image copyright Wolters Kluwer Health/Anatomical Chart Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201712</creationdate><title>Comparison of Localized and Systemic Otitis Media With ANCA-Associated Vasculitis</title><author>Okada, Masahiro ; Suemori, Koichiro ; Takagi, Daiki ; Teraoka, Masato ; Yamada, Hiroyuki ; Hato, Naohito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3563-3cf2c75d34da3bf6595a016e34142037b0905fd435defaeceab82bcb11deac8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications</topic><topic>Antibodies, Antineutrophil Cytoplasmic - blood</topic><topic>Audiometry</topic><topic>C-Reactive Protein - analysis</topic><topic>Female</topic><topic>Granulomatosis with Polyangiitis - complications</topic><topic>Humans</topic><topic>Interleukin-2 Receptor alpha Subunit - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Otitis Media - etiology</topic><topic>Recovery of Function</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Suemori, Koichiro</creatorcontrib><creatorcontrib>Takagi, Daiki</creatorcontrib><creatorcontrib>Teraoka, Masato</creatorcontrib><creatorcontrib>Yamada, Hiroyuki</creatorcontrib><creatorcontrib>Hato, Naohito</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otology & neurotology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Masahiro</au><au>Suemori, Koichiro</au><au>Takagi, Daiki</au><au>Teraoka, Masato</au><au>Yamada, Hiroyuki</au><au>Hato, Naohito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Localized and Systemic Otitis Media With ANCA-Associated Vasculitis</atitle><jtitle>Otology & neurotology</jtitle><addtitle>Otol Neurotol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>38</volume><issue>10</issue><spage>e506</spage><epage>e510</epage><pages>e506-e510</pages><issn>1531-7129</issn><eissn>1537-4505</eissn><abstract>OBJECTIVE:To investigate differences in immune activity based on the presence of multiple organ involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and whether hearing outcomes are different between patients with AAV localized to the ear and patients with systemic AAV.
STUDY DESIGN:Retrospective case review.
SETTING:University hospital.
PATIENTS:Twenty patients with otitis media with AAV (OMAAV) who met the criteria proposed by the OMAAV study group in Japan.
MAIN OUTCOME MEASURE(S):Serum levels of C-reactive protein, ANCA titer, soluble interleukin-2 receptor levels, and hearing outcome.
RESULTS:Thirteen patients had disease involvement of organs other than the ear (systemic OMAAV group); involvement was localized to the ear in seven patients (localized OMAAV group). Serum levels of C-reactive protein, ANCA titer, and soluble interleukin-2 receptor were not significantly different between the groups. Hearing levels at diagnosis and in remission were significantly worse in the localized OMAAV group compared with the systemic OMAAV group. Hearing gain was not significantly different between groups.
CONCLUSION:It is suggested that immune activity in patients with AAV localized to the ear is equivalent to activity in patients with systemic AAV. Therefore, we may need treatment for OMAAV equal in intensity to that for systemic AAV. As the hearing level at diagnosis was worse in patients with AAV localized to the ear than in patients with systemic AAV, earlier diagnosis may be needed to improve hearing outcome.</abstract><cop>United States</cop><pub>Copyright by Otology & Neurotology, Inc. Image copyright Wolters Kluwer Health/Anatomical Chart Company</pub><pmid>28885482</pmid><doi>10.1097/MAO.0000000000001563</doi></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications Antibodies, Antineutrophil Cytoplasmic - blood Audiometry C-Reactive Protein - analysis Female Granulomatosis with Polyangiitis - complications Humans Interleukin-2 Receptor alpha Subunit - metabolism Male Middle Aged Otitis Media - etiology Recovery of Function Retrospective Studies |
| title | Comparison of Localized and Systemic Otitis Media With ANCA-Associated Vasculitis |
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