Discovery of a Gene Family Critical to Wyosine Base Formation in a Subset of Phenylalanine-specific Transfer RNAs

A large number of post-transcriptional base modifications in transfer RNAs have been described (Sprinzl, M., Horn, C., Brown, M., Ioudovitch, A., and Steinberg, S. (1998) Nucleic Acids Res. 26, 148-153). These modifications enhance and expand tRNA function to increase cell viability. The intermediat...

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Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (45), p.37616-37622
Hauptverfasser:	Waas, William F., de Crécy-Lagard, Valérie, Schimmel, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid Chromatography, Thin Layer Gene Deletion Gene Expression Regulation, Fungal Genetic Complementation Test Guanosine - analogs & derivatives Guanosine - biosynthesis Guanosine - chemistry Heterocyclic Compounds, 3-Ring - chemistry Hydrolysis Molecular Structure Multigene Family Phylogeny RNA Processing, Post-Transcriptional - genetics RNA, Transfer, Amino Acyl - chemistry RNA, Transfer, Amino Acyl - genetics RNA, Transfer, Amino Acyl - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
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