Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics

Two novel classes of monospirocyclopiperazinium salts were designed, synthesized, and evaluated for their in vivo analgesic activities. Some interesting structure–activity relationships are revealed: (1) Spirocyclopiperazinium moiety is favorable to improve the analgesic activity; (2) The size and c...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-11, Vol.17 (22), p.6245-6249
Hauptverfasser:	Sun, Qi, Yue, Cai-Qin, Ye, Jia, Li, Chang-Ling, Cheng, Tie-Ming, Li, Run-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesic Analgesics Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Animals Biological and medical sciences Dimethylphenylpiperazinium Iodide - chemistry Dimethylphenylpiperazinium Iodide - pharmacology Drug Evaluation, Preclinical Medical sciences Mice Molecular Structure Monospirocyclopiperazinium salts Neuropharmacology Pain Measurement Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - chemistry Piperazines - pharmacology Salts Spiro Compounds - chemistry Spiro Compounds - pharmacology Structure-Activity Relationship Synthesis
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