Synthesis, in vitro inhibitory activity towards COX-2 and haemolytic activity of derivatives of Esculentoside A

Twenty-one derivatives of Esculentoside A were synthesized. The conversion of the carboxylic acid into amides can highly enhance their inhibitory activity towards COX-2, and also increased the haemolytic activity. Esculentoside A (EsA) has been reported to possess anti-inflammatory activity and sele...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-12, Vol.17 (23), p.6430-6433
Hauptverfasser:	Wu, Fei, Yi, Yanghua, Sun, Peng, Zhang, Dazhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cell Line Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - chemical synthesis Cyclooxygenase 2 Inhibitors - pharmacology Derivatives Esculentoside A Hemolysis - drug effects Hemolysis - physiology Humans Insecta Medical sciences Oleanolic Acid - analogs & derivatives Oleanolic Acid - chemical synthesis Oleanolic Acid - pharmacology Pharmacology. Drug treatments Rabbits Saponins - chemical synthesis Saponins - pharmacology Structure-Activity Relationship Synthesis
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