Foxp3 super(+)CD25 super(+)CD4 super(+) natural regulatory T cells in dominant self-tolerance and autoimmune disease

Naturally arising CD25 super(+)CD4 super(+) regulatory T (Treg) cells, most of which are produced by the normal thymus as a functionally mature T-cell subpopulation, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological im...

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Veröffentlicht in:Immunological reviews 2006-08, Vol.212 (1), p.8-27
Hauptverfasser: Sakaguchi, Shimon, Ono, Masahiro, Setoguchi, Ruka, Yagi, Haruhiko, Hori, Shohei, Fehervari, Zoltan, Shimizu, Jun, Takahashi, Takeshi, Nomura, Takashi
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Sprache:eng
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