Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin
Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for nove...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2017-10, Vol.101 (20), p.7487-7496 |
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| creator | Marino-Merlo, Francesca Papaianni, Emanuela Maugeri, Teresa L. Zammuto, Vincenzo Spanò, Antonio Nicolaus, Barbara Poli, Annarita Di Donato, Paola Mosca, Claudia Mastino, Antonio Gugliandolo, Concetta |
| description | Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-γ-glutamic acid (γ-PGA-APA), produced by the marine thermotolerant
Bacillus horneckiae
strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties. The biopolymer hindered the HSV-1 infection in the very early phase of virus replication. In addition, the γ-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-α and IL-1β gene expression. Moreover, the capacity to positively modulate the transcriptional activity of the cytokine genes was paired with increased level of activation of the transcription factor NF-kB by γ-PGA-APA. Overall, as non-cytotoxic biopolymer able to contribute in the antiviral defense against HSV-1, γ-PGA-APA could lead to the development of novel natural drugs for alternative therapies. |
| doi_str_mv | 10.1007/s00253-017-8472-5 |
| format | Article |
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Bacillus horneckiae
strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties. The biopolymer hindered the HSV-1 infection in the very early phase of virus replication. In addition, the γ-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-α and IL-1β gene expression. Moreover, the capacity to positively modulate the transcriptional activity of the cytokine genes was paired with increased level of activation of the transcription factor NF-kB by γ-PGA-APA. Overall, as non-cytotoxic biopolymer able to contribute in the antiviral defense against HSV-1, γ-PGA-APA could lead to the development of novel natural drugs for alternative therapies.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-017-8472-5</identifier><identifier>PMID: 28879435</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antiviral activity ; Antiviral agents ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Bacillus ; Bacillus - isolation & purification ; Bacillus - metabolism ; Biological activity ; Biomedical and Life Sciences ; Biopolymers ; Biotechnological Products and Process Engineering ; Biotechnology ; Central nervous system ; Cytokines - biosynthesis ; Cytotoxicity ; Drug development ; Gene expression ; Gene Expression - drug effects ; Glutamic acid ; Herpes simplex ; Herpes viruses ; Herpesvirus 1, Human - drug effects ; Herpesvirus 1, Human - physiology ; IL-1β ; Immunologic Factors - isolation & purification ; Immunologic Factors - pharmacology ; Immunomodulation ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; NF-kappa B - metabolism ; NF-κB protein ; poly-γ-Glutamic acid ; Polyglutamic Acid - analogs & derivatives ; Polyglutamic Acid - isolation & purification ; Polyglutamic Acid - pharmacology ; Toxicity ; Transcription activation ; Transcription, Genetic - drug effects ; Tumor necrosis factor ; Virus Replication - drug effects ; Viruses</subject><ispartof>Applied microbiology and biotechnology, 2017-10, Vol.101 (20), p.7487-7496</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-54095ee6ffb2b2633cc5c63fcf3ec60c3b7a008262db93031e421c6662ded8633</citedby><cites>FETCH-LOGICAL-c420t-54095ee6ffb2b2633cc5c63fcf3ec60c3b7a008262db93031e421c6662ded8633</cites><orcidid>0000-0002-0338-6450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-017-8472-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-017-8472-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28879435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marino-Merlo, Francesca</creatorcontrib><creatorcontrib>Papaianni, Emanuela</creatorcontrib><creatorcontrib>Maugeri, Teresa L.</creatorcontrib><creatorcontrib>Zammuto, Vincenzo</creatorcontrib><creatorcontrib>Spanò, Antonio</creatorcontrib><creatorcontrib>Nicolaus, Barbara</creatorcontrib><creatorcontrib>Poli, Annarita</creatorcontrib><creatorcontrib>Di Donato, Paola</creatorcontrib><creatorcontrib>Mosca, Claudia</creatorcontrib><creatorcontrib>Mastino, Antonio</creatorcontrib><creatorcontrib>Gugliandolo, Concetta</creatorcontrib><title>Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-γ-glutamic acid (γ-PGA-APA), produced by the marine thermotolerant
Bacillus horneckiae
strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties. The biopolymer hindered the HSV-1 infection in the very early phase of virus replication. In addition, the γ-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-α and IL-1β gene expression. Moreover, the capacity to positively modulate the transcriptional activity of the cytokine genes was paired with increased level of activation of the transcription factor NF-kB by γ-PGA-APA. Overall, as non-cytotoxic biopolymer able to contribute in the antiviral defense against HSV-1, γ-PGA-APA could lead to the development of novel natural drugs for alternative therapies.</description><subject>Antiviral activity</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Bacillus</subject><subject>Bacillus - isolation & purification</subject><subject>Bacillus - metabolism</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biopolymers</subject><subject>Biotechnological Products and Process Engineering</subject><subject>Biotechnology</subject><subject>Central nervous system</subject><subject>Cytokines - biosynthesis</subject><subject>Cytotoxicity</subject><subject>Drug development</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Glutamic acid</subject><subject>Herpes simplex</subject><subject>Herpes viruses</subject><subject>Herpesvirus 1, Human - 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Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marino-Merlo, Francesca</au><au>Papaianni, Emanuela</au><au>Maugeri, Teresa L.</au><au>Zammuto, Vincenzo</au><au>Spanò, Antonio</au><au>Nicolaus, Barbara</au><au>Poli, Annarita</au><au>Di Donato, Paola</au><au>Mosca, Claudia</au><au>Mastino, Antonio</au><au>Gugliandolo, Concetta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>101</volume><issue>20</issue><spage>7487</spage><epage>7496</epage><pages>7487-7496</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Herpes simplex virus type 1 (HSV-1) is responsible of common and widespread viral infections in humans through the world, and of rare, but extremely severe, clinical syndromes in the central nervous system. The emergence of resistant strains to drugs actually in use encourages the searching for novel antiviral compounds, including those of natural origin. In this study, the recently described poly-γ-glutamic acid (γ-PGA-APA), produced by the marine thermotolerant
Bacillus horneckiae
strain APA, and previously shown to possess biological and antiviral activity, was evaluated for its anti-HSV-1 and immunomodulatory properties. The biopolymer hindered the HSV-1 infection in the very early phase of virus replication. In addition, the γ-PGA-APA was shown to exert low cytotoxicity and noticeable immunomodulatory activities towards TNF-α and IL-1β gene expression. Moreover, the capacity to positively modulate the transcriptional activity of the cytokine genes was paired with increased level of activation of the transcription factor NF-kB by γ-PGA-APA. Overall, as non-cytotoxic biopolymer able to contribute in the antiviral defense against HSV-1, γ-PGA-APA could lead to the development of novel natural drugs for alternative therapies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28879435</pmid><doi>10.1007/s00253-017-8472-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0338-6450</orcidid></addata></record> |
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| subjects | Antiviral activity Antiviral agents Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Bacillus Bacillus - isolation & purification Bacillus - metabolism Biological activity Biomedical and Life Sciences Biopolymers Biotechnological Products and Process Engineering Biotechnology Central nervous system Cytokines - biosynthesis Cytotoxicity Drug development Gene expression Gene Expression - drug effects Glutamic acid Herpes simplex Herpes viruses Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - physiology IL-1β Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunomodulation Life Sciences Microbial Genetics and Genomics Microbiology NF-kappa B - metabolism NF-κB protein poly-γ-Glutamic acid Polyglutamic Acid - analogs & derivatives Polyglutamic Acid - isolation & purification Polyglutamic Acid - pharmacology Toxicity Transcription activation Transcription, Genetic - drug effects Tumor necrosis factor Virus Replication - drug effects Viruses |
| title | Anti-herpes simplex virus 1 and immunomodulatory activities of a poly-γ- glutamic acid from Bacillus horneckiae strain APA of shallow vent origin |
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