[Omega]-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence

A series of [Omega]-alkoxy ethers were prepared with variation of the length of the aliphatic chain of suberoylanilide hydroxamic acid (SAHA, vorinostat). Eight carbon long chain analogues showed the best activity, among which several substituted benzyl ether derivatives exhibited inhibitory activit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-11, Vol.17 (22), p.6261-6265
Hauptverfasser:	Hanessian, Stephen, Auzzas, Luciana, Giannini, Giuseppe, Marzi, Mauro, Cabri, Walter, Barbarino, Marcella, Vesci, Loredana, Pisano, Claudio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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