Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae

The stercoselective synthesis of naphthoquinone 1 and its biological evaluation are reported. Stereoselective synthesis of 1, one of biologically active naphthoquinones from a Brazilian traditional medicine Tabebuia avellanedae, was achieved by utilizing Noyori reduction as a key step. Compound 1 di...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-12, Vol.17 (23), p.6417-6420
Hauptverfasser:	Yamashita, Mitsuaki, Kaneko, Masafumi, Iida, Akira, Tokuda, Harukuni, Nishimura, Katsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - toxicity Antitumor activity Biological and medical sciences Cancer chemoprevention Carcinogenesis, carcinogens and anticarcinogens Cell Line, Tumor Chemical agents General aspects General pharmacology Humans Medical sciences Molecular Conformation Naphtho[2,3- b]furan-4,9-dione Naphthoquinones - chemical synthesis Naphthoquinones - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemical synthesis Plant Extracts - toxicity Stereoselective synthesis Tabebuia Tabebuia avellanedae Tumors
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