Expression of apoptosis-associated molecules in the fetoplacental unit of cyclophosphamide-treated mice

The mechanisms underlying the teratogen-induced apoptotic process leading to anomaly formation are not as yet understood. Therefore, we tried to evaluate possible changes in the expression of molecules regulating the apoptotic process induced in the embryo and placenta by exposure to cyclophosphamid...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2006-11, Vol.22 (4), p.774-782
Hauptverfasser:	Mammon, Keren, Savion, Shoshana, Keshet, Rotem, Aroch, Ilan, Orenstein, Hasida, Fein, Amos, Torchinsky, Arkady, Toder, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bax bcl-2-Associated X Protein - metabolism Biological and medical sciences Blotting, Western Cell Cycle - drug effects Cell Proliferation - drug effects Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - toxicity Embryo Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects Fetus - metabolism Flow Cytometry - methods Fundamental and applied biological sciences. Psychology G1 Phase - drug effects Gestational Age I-kappa B Proteins - metabolism Immunochemistry In Situ Nick-End Labeling - methods Injections, Intraperitoneal IκBα Male Medical sciences Mice Mice, Inbred ICR Mutagens - administration & dosage Mutagens - toxicity p65 Placenta Placenta - drug effects Placenta - metabolism Pregnancy Synaptotagmin I - metabolism Teratogen Teratology. Teratogens Toxicology
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