Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib
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| Veröffentlicht in: | Molecular and Cellular Biology 2006-08, Vol.26 (16), p.6082-6093 |
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| creator | Griswold, Ian J. MacPartlin, Mary Bumm, Thomas Goss, Valerie L. O'Hare, Thomas Lee, Kimberly A. Corbin, Amie S. Stoffregen, Eric P. Smith, Caitlyn Johnson, Kara Moseson, Erika M. Wood, Lisa J. Polakiewicz, Roberto D. Druker, Brian J. Deininger, Michael W. |
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| doi_str_mv | 10.1128/MCB.02202-05 |
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</description><identifier>ISSN: 0270-7306</identifier><identifier>ISSN: 1098-5549</identifier><identifier>EISSN: 1098-5549</identifier><identifier>DOI: 10.1128/MCB.02202-05</identifier><identifier>PMID: 16880519</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Amino Acid Sequence ; Animals ; Benzamides ; Cell Proliferation ; Cell Survival ; Cell Transformation, Neoplastic - drug effects ; Cells, Cultured ; Colony-Forming Units Assay ; Disease Models, Animal ; Female ; Fusion Proteins, bcr-abl - chemistry ; Fusion Proteins, bcr-abl - genetics ; Fusion Proteins, bcr-abl - metabolism ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Mutation - genetics ; Myeloid Progenitor Cells - cytology ; Phosphotransferases - metabolism ; Phosphotyrosine - metabolism ; Piperazines - pharmacology ; Protein Structure, Tertiary ; Pyrimidines - pharmacology ; Signal Transduction ; Substrate Specificity</subject><ispartof>Molecular and Cellular Biology, 2006-08, Vol.26 (16), p.6082-6093</ispartof><rights>Copyright © 2006 American Society for Microbiology 2006</rights><rights>Copyright © 2006, American Society for Microbiology 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-cc003081fc5ba4a6991dbf6423e57f1e6c14734ecb36c0123b014296cd55907c3</citedby><cites>FETCH-LOGICAL-c554t-cc003081fc5ba4a6991dbf6423e57f1e6c14734ecb36c0123b014296cd55907c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592813/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592813/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16880519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griswold, Ian J.</creatorcontrib><creatorcontrib>MacPartlin, Mary</creatorcontrib><creatorcontrib>Bumm, Thomas</creatorcontrib><creatorcontrib>Goss, Valerie L.</creatorcontrib><creatorcontrib>O'Hare, Thomas</creatorcontrib><creatorcontrib>Lee, Kimberly A.</creatorcontrib><creatorcontrib>Corbin, Amie S.</creatorcontrib><creatorcontrib>Stoffregen, Eric P.</creatorcontrib><creatorcontrib>Smith, Caitlyn</creatorcontrib><creatorcontrib>Johnson, Kara</creatorcontrib><creatorcontrib>Moseson, Erika M.</creatorcontrib><creatorcontrib>Wood, Lisa J.</creatorcontrib><creatorcontrib>Polakiewicz, Roberto D.</creatorcontrib><creatorcontrib>Druker, Brian J.</creatorcontrib><creatorcontrib>Deininger, Michael W.</creatorcontrib><title>Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib</title><title>Molecular and Cellular Biology</title><addtitle>Mol Cell Biol</addtitle><description>Article Usage Stats
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</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Benzamides</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Cells, Cultured</subject><subject>Colony-Forming Units Assay</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fusion Proteins, bcr-abl - chemistry</subject><subject>Fusion Proteins, bcr-abl - genetics</subject><subject>Fusion Proteins, bcr-abl - metabolism</subject><subject>Humans</subject><subject>Imatinib Mesylate</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>Myeloid Progenitor Cells - cytology</subject><subject>Phosphotransferases - metabolism</subject><subject>Phosphotyrosine - metabolism</subject><subject>Piperazines - pharmacology</subject><subject>Protein Structure, Tertiary</subject><subject>Pyrimidines - pharmacology</subject><subject>Signal Transduction</subject><subject>Substrate Specificity</subject><issn>0270-7306</issn><issn>1098-5549</issn><issn>1098-5549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v0zAYhyMEYmVw44wsDpya8dqOnfiC1JUBFZtA2na2HMdZjRK72M627rPwYUmbij8HxMmS_fwev69-WfYSwwnGpHp7sTw9AUKA5MAeZTMMosoZK8TjbAakhLykwI-yZzF-AwAugD7NjjCvKmBYzLIfn61T0aD3vlfWoYshKZci8i061SFf1B06u1_b2ia06JIJpkFXQbnY-tCrZL1DX30yTm_n6CBa6GRvbRovlGvQ5VDHFFQy6DrZzj7sM3O0CsHEjdmhZvfXpXHRTjmUPFrt3M7Wz7MnreqieXE4j7PrD2dXy0_5-ZePq-XiPNfjoinXGoBChVvNalUoLgRu6pYXhBpWtthwjYuSFkbXlGvAhNaACyK4bhgTUGp6nL2bvJuh7k2jjRtn7uQm2F6FrfTKyr9fnF3LG38rMROkwnQUvDkIgv8-mJhkb6M2Xaec8UOUvCqBsBL-C2JBOeWVGMH5BOrgYwym_TUNBrnrXY69y33vEtiIv_pzg9_woegRKCfAun13dz50jUxq2_nQjo1qGyX9h_r1lFzbm_WdDUaq2Mte15Lw0S85VIT-BKBVyTc</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Griswold, Ian J.</creator><creator>MacPartlin, Mary</creator><creator>Bumm, Thomas</creator><creator>Goss, Valerie L.</creator><creator>O'Hare, Thomas</creator><creator>Lee, Kimberly A.</creator><creator>Corbin, Amie S.</creator><creator>Stoffregen, Eric P.</creator><creator>Smith, Caitlyn</creator><creator>Johnson, Kara</creator><creator>Moseson, Erika M.</creator><creator>Wood, Lisa J.</creator><creator>Polakiewicz, Roberto D.</creator><creator>Druker, Brian J.</creator><creator>Deininger, Michael W.</creator><general>American Society for Microbiology</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060801</creationdate><title>Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib</title><author>Griswold, Ian J. ; 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Benzamides Cell Proliferation Cell Survival Cell Transformation, Neoplastic - drug effects Cells, Cultured Colony-Forming Units Assay Disease Models, Animal Female Fusion Proteins, bcr-abl - chemistry Fusion Proteins, bcr-abl - genetics Fusion Proteins, bcr-abl - metabolism Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Mice Mice, Inbred BALB C Molecular Sequence Data Mutation - genetics Myeloid Progenitor Cells - cytology Phosphotransferases - metabolism Phosphotyrosine - metabolism Piperazines - pharmacology Protein Structure, Tertiary Pyrimidines - pharmacology Signal Transduction Substrate Specificity |
| title | Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib |
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