Folate, vitamin B12, homocysteine and polymorphisms in folate metabolizing genes in children with congenital heart disease and their mothers

Background/Objectives: The objective of the study was to assess the role of variations in serum folate, vitamin B12, homocysteine and the presence of genetic polymorphisms as risk factors for congenital heart disease (CHD) in children. Subjects/Methods: A total of 32 children with CHD, and their mot...

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Veröffentlicht in:	European journal of clinical nutrition 2017-12, Vol.71 (12), p.1437-1441
Hauptverfasser:	Elizabeth, K E, Praveen, S L, Preethi, N R, Jissa, V T, Pillai, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/77 631/61/212 692/308/2056 Adult Analysis Cardiovascular disease Cardiovascular diseases Case-Control Studies Child Child, Preschool Children Clinical Nutrition Complications and side effects Congenital diseases Congenital heart defects Congenital heart disease Coronary artery disease Cyanocobalamin Diet therapy Dietary supplements Distribution Epidemiology Ferredoxin-NADP Reductase - genetics Folic acid Folic Acid - blood Gene polymorphism Gene-Environment Interaction Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Health aspects Health risk assessment Heart Defects, Congenital - blood Heart Defects, Congenital - genetics Heart diseases Homocysteine Homocysteine - blood Humans Infant Internal Medicine Measurement Medicine Medicine & Public Health Metabolic Diseases Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Mothers Multivariate analysis Nutrients original-article Pediatric research Physiological aspects Polymorphism Polymorphism, Single Nucleotide Prenatal influences Public Health Risk analysis Risk Factors Socioeconomic Factors Supplements Vitamin B Vitamin B 12 - blood Vitamin B12 Vitamin B12 deficiency Young Adult
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Zusammenfassung:	Background/Objectives: The objective of the study was to assess the role of variations in serum folate, vitamin B12, homocysteine and the presence of genetic polymorphisms as risk factors for congenital heart disease (CHD) in children. Subjects/Methods: A total of 32 children with CHD, and their mothers and 32 normal children and their mothers formed the study and control groups, respectively. Serum folate, vitamin B12 and homocysteine as well as genetic polymorphisms MTHFR C677→T, MTHFR A1298→C, MTR A2756→G and MTRR A66→G were assessed. Results: Low serum folate and genetic polymorphisms MTHFR C677→T and MTRR A66→G among children and their mothers and high homocysteine among mothers were noted as risk factors for CHD ( P
ISSN:	0954-3007 1476-5640
DOI:	10.1038/ejcn.2017.135