Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells
Aim: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Catio...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2017-10, Vol.12 (19), p.2319-2333 |
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| container_title | Nanomedicine (London, England) |
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| creator | Fatma Demir Duman Erkisa, Merve Khodadust, Rouhullah Ferda Ari Ulukaya, Engin Havva Yagci Acar |
| description | Aim: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging. |
| doi_str_mv | 10.2217/nnm-2017-0180 |
| format | Article |
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Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2017-0180</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>Acids ; Apoptosis ; Cancer therapies ; Cervical cancer ; Chemotherapy ; Cytotoxicity ; Drug delivery systems ; Drug efficacy ; Drugs ; Nanoparticles ; Polyethylene glycol ; Quantum dots ; Vitamin B</subject><ispartof>Nanomedicine (London, England), 2017-10, Vol.12 (19), p.2319-2333</ispartof><rights>Copyright Future Medicine Ltd Oct 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Fatma Demir Duman</creatorcontrib><creatorcontrib>Erkisa, Merve</creatorcontrib><creatorcontrib>Khodadust, Rouhullah</creatorcontrib><creatorcontrib>Ferda Ari</creatorcontrib><creatorcontrib>Ulukaya, Engin</creatorcontrib><creatorcontrib>Havva Yagci Acar</creatorcontrib><title>Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells</title><title>Nanomedicine (London, England)</title><description>Aim: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. 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Erkisa, Merve ; Khodadust, Rouhullah ; Ferda Ari ; Ulukaya, Engin ; Havva Yagci Acar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p216t-830c30cb050564f79e3c139ea11518856fc1aa99c54e0b96187a0670e38ddc913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cervical cancer</topic><topic>Chemotherapy</topic><topic>Cytotoxicity</topic><topic>Drug delivery systems</topic><topic>Drug efficacy</topic><topic>Drugs</topic><topic>Nanoparticles</topic><topic>Polyethylene glycol</topic><topic>Quantum dots</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatma Demir Duman</creatorcontrib><creatorcontrib>Erkisa, Merve</creatorcontrib><creatorcontrib>Khodadust, Rouhullah</creatorcontrib><creatorcontrib>Ferda Ari</creatorcontrib><creatorcontrib>Ulukaya, Engin</creatorcontrib><creatorcontrib>Havva Yagci Acar</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatma Demir Duman</au><au>Erkisa, Merve</au><au>Khodadust, Rouhullah</au><au>Ferda Ari</au><au>Ulukaya, Engin</au><au>Havva Yagci Acar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells</atitle><jtitle>Nanomedicine (London, England)</jtitle><date>2017-10-01</date><risdate>2017</risdate><volume>12</volume><issue>19</issue><spage>2319</spage><epage>2333</epage><pages>2319-2333</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Aim: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.</abstract><cop>London</cop><pub>Future Medicine Ltd</pub><doi>10.2217/nnm-2017-0180</doi><tpages>15</tpages></addata></record> |
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| subjects | Acids Apoptosis Cancer therapies Cervical cancer Chemotherapy Cytotoxicity Drug delivery systems Drug efficacy Drugs Nanoparticles Polyethylene glycol Quantum dots Vitamin B |
| title | Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells |
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