Site- and species-specific hydrolysis rates of cocaine

[Display omitted] •Protonation macro- and microconstants of cocaine and its derivatives were determined.•Site- and species-specific hydrolysis rate constants of cocaine and its hydrolysis products were detemined.•The experiments were performed with NMR spectroscopy.•Nitrogen protonation accelerates...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2017-10, Vol.145, p.372-378
Hauptverfasser:	Szöcs, Levente, Völgyi, Gergely, Urai, Ákos, Hosztafi, Sándor, Tóth, Gergő, Gergó, Lajos, Noszál, Béla
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium Cocaine Cocaine - chemistry Ester hydrolysis Hydrolysis Microconstant Nitrogen Protonation Rate constant Species Specificity
Online-Zugang:	Volltext
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