A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region
Objective This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda sy...
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| Veröffentlicht in: | Diagnostic cytopathology 2017-11, Vol.45 (11), p.983-988 |
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| creator | Al‐Abbadi, Mousa A. Shareef, Sameera Q. Yousef, Mohammad M. Almasri, Nidal M. Mustafa, Huda E. Aljawad, Hameed Ali, Jassim A. Groves, Alan Alsaihati, Yasmen |
| description | Objective
This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting thyroid cytology (TBSRTC).
Materials and Methods
The archival materials of all thyroid fine‐needle aspirates over a 5‐year period were retrieved from 3 institutions in the Arabian Gulf Region. All cytology slides and follow‐up material for cases interpreted as AUS/FLUS and FN/SFN were reviewed. The revised diagnoses and follow‐up were recorded. Analysis of risk of malignancy was calculated for the 2 entities.
Results
A total number of 2592 thyroid fine‐needle aspirates were performed, out of which AUS/FLUS was found in 115 (4.4%) while FN/SFN in 39 (1.5%). Follow‐up by surgery or repeat FNA was conducted on 42 (27%) and 10 (7%) patients on these 2 categories, respectively. The risk of malignancy was found to be 29% and 45%, respectively.
Conclusion
The risk of malignancy for AUS/FLUS and FN/SFN are 29% and 45%, respectively. This risk of malignancy in our study is on the higher range of that reported in the literature. |
| doi_str_mv | 10.1002/dc.23805 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1936166444</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1936166444</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3495-e47740537a8f7ff46ad584c30b9189bd2dcb176c4faffd08ec5dbf3fe2b757693</originalsourceid><addsrcrecordid>eNp9kk2KFDEYhoMoTjsKnkACbtzUdFJJVRJ3TaujMOBG10UqP2OGVFImFYbaeQTP6Bk8gGm7_UHUVSDfk4f3JR8AjzG6wAi1W60uWsJRdwdsMBKsQYSIu2DDWdc1GBFxBh7kfIMQEi3u74OzlvO-5RhtwNcdtNH7ePvl0-cyw7wUvcIY4PJhTdFpKPPsklxMhsnMMS3mcAXlss5OwmhhCdosJk0u1El218FZp2RQZnvQOlW8TNCb7KrzfziUQcPfngQTZy_ztM2lJlAullzH6W_Ic7iDU_GLUyZU96mDTXGqLQzcJTk6GeBl8baWuK5JHoJ7VvpsHp3Oc_D-1ct3-9fN1dvLN_vdVaMIFV1jKGMUdYRJbpm1tJe641QRNArMxahbrUbMekWttFYjblSnR0usaUfWsV6Qc_Ds6J1T_FhMXobJZWW8lzV7yQMWpMd9Tymt6NM_0JtYUqjpKkW5QIxT8kuoUsw5GTvMyU0yrQNGw2ETBq2G75tQ0ScnYRkno3-CP76-As0RuHXerP8UDS_2R-E3LBHE4A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1948907843</pqid></control><display><type>article</type><title>A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Al‐Abbadi, Mousa A. ; Shareef, Sameera Q. ; Yousef, Mohammad M. ; Almasri, Nidal M. ; Mustafa, Huda E. ; Aljawad, Hameed ; Ali, Jassim A. ; Groves, Alan ; Alsaihati, Yasmen</creator><creatorcontrib>Al‐Abbadi, Mousa A. ; Shareef, Sameera Q. ; Yousef, Mohammad M. ; Almasri, Nidal M. ; Mustafa, Huda E. ; Aljawad, Hameed ; Ali, Jassim A. ; Groves, Alan ; Alsaihati, Yasmen</creatorcontrib><description>Objective
This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting thyroid cytology (TBSRTC).
Materials and Methods
The archival materials of all thyroid fine‐needle aspirates over a 5‐year period were retrieved from 3 institutions in the Arabian Gulf Region. All cytology slides and follow‐up material for cases interpreted as AUS/FLUS and FN/SFN were reviewed. The revised diagnoses and follow‐up were recorded. Analysis of risk of malignancy was calculated for the 2 entities.
Results
A total number of 2592 thyroid fine‐needle aspirates were performed, out of which AUS/FLUS was found in 115 (4.4%) while FN/SFN in 39 (1.5%). Follow‐up by surgery or repeat FNA was conducted on 42 (27%) and 10 (7%) patients on these 2 categories, respectively. The risk of malignancy was found to be 29% and 45%, respectively.
Conclusion
The risk of malignancy for AUS/FLUS and FN/SFN are 29% and 45%, respectively. This risk of malignancy in our study is on the higher range of that reported in the literature.</description><identifier>ISSN: 8755-1039</identifier><identifier>EISSN: 1097-0339</identifier><identifier>DOI: 10.1002/dc.23805</identifier><identifier>PMID: 28862810</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma, Follicular - epidemiology ; Adenocarcinoma, Follicular - pathology ; Adult ; Aged ; AUS/FLUS ; Cellular biology ; Cytology ; Diagnosis, Differential ; Female ; FN/suspicious for FN ; follow‐up ; Health risk assessment ; Humans ; Institutions ; Male ; Malignancy ; Middle Aged ; Middle East ; Risk analysis ; Thyroid ; Thyroid gland ; Thyroid Nodule - epidemiology ; Thyroid Nodule - pathology ; Tumors</subject><ispartof>Diagnostic cytopathology, 2017-11, Vol.45 (11), p.983-988</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3495-e47740537a8f7ff46ad584c30b9189bd2dcb176c4faffd08ec5dbf3fe2b757693</citedby><cites>FETCH-LOGICAL-c3495-e47740537a8f7ff46ad584c30b9189bd2dcb176c4faffd08ec5dbf3fe2b757693</cites><orcidid>0000-0002-0467-8244</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdc.23805$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdc.23805$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28862810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Abbadi, Mousa A.</creatorcontrib><creatorcontrib>Shareef, Sameera Q.</creatorcontrib><creatorcontrib>Yousef, Mohammad M.</creatorcontrib><creatorcontrib>Almasri, Nidal M.</creatorcontrib><creatorcontrib>Mustafa, Huda E.</creatorcontrib><creatorcontrib>Aljawad, Hameed</creatorcontrib><creatorcontrib>Ali, Jassim A.</creatorcontrib><creatorcontrib>Groves, Alan</creatorcontrib><creatorcontrib>Alsaihati, Yasmen</creatorcontrib><title>A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region</title><title>Diagnostic cytopathology</title><addtitle>Diagn Cytopathol</addtitle><description>Objective
This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting thyroid cytology (TBSRTC).
Materials and Methods
The archival materials of all thyroid fine‐needle aspirates over a 5‐year period were retrieved from 3 institutions in the Arabian Gulf Region. All cytology slides and follow‐up material for cases interpreted as AUS/FLUS and FN/SFN were reviewed. The revised diagnoses and follow‐up were recorded. Analysis of risk of malignancy was calculated for the 2 entities.
Results
A total number of 2592 thyroid fine‐needle aspirates were performed, out of which AUS/FLUS was found in 115 (4.4%) while FN/SFN in 39 (1.5%). Follow‐up by surgery or repeat FNA was conducted on 42 (27%) and 10 (7%) patients on these 2 categories, respectively. The risk of malignancy was found to be 29% and 45%, respectively.
Conclusion
The risk of malignancy for AUS/FLUS and FN/SFN are 29% and 45%, respectively. This risk of malignancy in our study is on the higher range of that reported in the literature.</description><subject>Adenocarcinoma, Follicular - epidemiology</subject><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>AUS/FLUS</subject><subject>Cellular biology</subject><subject>Cytology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>FN/suspicious for FN</subject><subject>follow‐up</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Institutions</subject><subject>Male</subject><subject>Malignancy</subject><subject>Middle Aged</subject><subject>Middle East</subject><subject>Risk analysis</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Nodule - epidemiology</subject><subject>Thyroid Nodule - pathology</subject><subject>Tumors</subject><issn>8755-1039</issn><issn>1097-0339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2KFDEYhoMoTjsKnkACbtzUdFJJVRJ3TaujMOBG10UqP2OGVFImFYbaeQTP6Bk8gGm7_UHUVSDfk4f3JR8AjzG6wAi1W60uWsJRdwdsMBKsQYSIu2DDWdc1GBFxBh7kfIMQEi3u74OzlvO-5RhtwNcdtNH7ePvl0-cyw7wUvcIY4PJhTdFpKPPsklxMhsnMMS3mcAXlss5OwmhhCdosJk0u1El218FZp2RQZnvQOlW8TNCb7KrzfziUQcPfngQTZy_ztM2lJlAullzH6W_Ic7iDU_GLUyZU96mDTXGqLQzcJTk6GeBl8baWuK5JHoJ7VvpsHp3Oc_D-1ct3-9fN1dvLN_vdVaMIFV1jKGMUdYRJbpm1tJe641QRNArMxahbrUbMekWttFYjblSnR0usaUfWsV6Qc_Ds6J1T_FhMXobJZWW8lzV7yQMWpMd9Tymt6NM_0JtYUqjpKkW5QIxT8kuoUsw5GTvMyU0yrQNGw2ETBq2G75tQ0ScnYRkno3-CP76-As0RuHXerP8UDS_2R-E3LBHE4A</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Al‐Abbadi, Mousa A.</creator><creator>Shareef, Sameera Q.</creator><creator>Yousef, Mohammad M.</creator><creator>Almasri, Nidal M.</creator><creator>Mustafa, Huda E.</creator><creator>Aljawad, Hameed</creator><creator>Ali, Jassim A.</creator><creator>Groves, Alan</creator><creator>Alsaihati, Yasmen</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0467-8244</orcidid></search><sort><creationdate>201711</creationdate><title>A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region</title><author>Al‐Abbadi, Mousa A. ; Shareef, Sameera Q. ; Yousef, Mohammad M. ; Almasri, Nidal M. ; Mustafa, Huda E. ; Aljawad, Hameed ; Ali, Jassim A. ; Groves, Alan ; Alsaihati, Yasmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3495-e47740537a8f7ff46ad584c30b9189bd2dcb176c4faffd08ec5dbf3fe2b757693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma, Follicular - epidemiology</topic><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>AUS/FLUS</topic><topic>Cellular biology</topic><topic>Cytology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>FN/suspicious for FN</topic><topic>follow‐up</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Institutions</topic><topic>Male</topic><topic>Malignancy</topic><topic>Middle Aged</topic><topic>Middle East</topic><topic>Risk analysis</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Nodule - epidemiology</topic><topic>Thyroid Nodule - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Abbadi, Mousa A.</creatorcontrib><creatorcontrib>Shareef, Sameera Q.</creatorcontrib><creatorcontrib>Yousef, Mohammad M.</creatorcontrib><creatorcontrib>Almasri, Nidal M.</creatorcontrib><creatorcontrib>Mustafa, Huda E.</creatorcontrib><creatorcontrib>Aljawad, Hameed</creatorcontrib><creatorcontrib>Ali, Jassim A.</creatorcontrib><creatorcontrib>Groves, Alan</creatorcontrib><creatorcontrib>Alsaihati, Yasmen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Abbadi, Mousa A.</au><au>Shareef, Sameera Q.</au><au>Yousef, Mohammad M.</au><au>Almasri, Nidal M.</au><au>Mustafa, Huda E.</au><au>Aljawad, Hameed</au><au>Ali, Jassim A.</au><au>Groves, Alan</au><au>Alsaihati, Yasmen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region</atitle><jtitle>Diagnostic cytopathology</jtitle><addtitle>Diagn Cytopathol</addtitle><date>2017-11</date><risdate>2017</risdate><volume>45</volume><issue>11</issue><spage>983</spage><epage>988</epage><pages>983-988</pages><issn>8755-1039</issn><eissn>1097-0339</eissn><abstract>Objective
This is a multicenter study which was conducted to evaluate the follow‐up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting thyroid cytology (TBSRTC).
Materials and Methods
The archival materials of all thyroid fine‐needle aspirates over a 5‐year period were retrieved from 3 institutions in the Arabian Gulf Region. All cytology slides and follow‐up material for cases interpreted as AUS/FLUS and FN/SFN were reviewed. The revised diagnoses and follow‐up were recorded. Analysis of risk of malignancy was calculated for the 2 entities.
Results
A total number of 2592 thyroid fine‐needle aspirates were performed, out of which AUS/FLUS was found in 115 (4.4%) while FN/SFN in 39 (1.5%). Follow‐up by surgery or repeat FNA was conducted on 42 (27%) and 10 (7%) patients on these 2 categories, respectively. The risk of malignancy was found to be 29% and 45%, respectively.
Conclusion
The risk of malignancy for AUS/FLUS and FN/SFN are 29% and 45%, respectively. This risk of malignancy in our study is on the higher range of that reported in the literature.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28862810</pmid><doi>10.1002/dc.23805</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0467-8244</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-1039 |
| ispartof | Diagnostic cytopathology, 2017-11, Vol.45 (11), p.983-988 |
| issn | 8755-1039 1097-0339 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adenocarcinoma, Follicular - epidemiology Adenocarcinoma, Follicular - pathology Adult Aged AUS/FLUS Cellular biology Cytology Diagnosis, Differential Female FN/suspicious for FN follow‐up Health risk assessment Humans Institutions Male Malignancy Middle Aged Middle East Risk analysis Thyroid Thyroid gland Thyroid Nodule - epidemiology Thyroid Nodule - pathology Tumors |
| title | A follow‐up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region |
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