Overexpression of Heparin-binding Epidermal Growth Factor-like Growth Factor Mediates Liver Fibrosis in Transgenic Mice

Abstract Background The role of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in liver fibrosis is not clear and is sometimes even contradictory. To clarify this role, a HB-EGF transgenic (Tg) mouse model was, for the first time, used to evaluate the functions of HB-EGF in live...

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Veröffentlicht in:	The American journal of the medical sciences 2017-08, Vol.354 (2), p.199-210
Hauptverfasser:	Guo, Yongze, PhD, Ding, Qian, PhD, Chen, Lei, PhD, Ji, Chenguang, PhD, Hao, Huiyao, PhD, Wang, Jia, PhD, Qi, Wei, PhD, Xie, Xiaoli, PhD, Ma, Junji, PhD, Li, Aidi, PhD, Jiang, Xiaoyu, PhD, Li, Xiaotian, PhD, Jiang, Huiqing, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Tetrachloride - toxicity Collagen - metabolism Gene Expression Regulation, Neoplastic Heparin-binding EGF-like Growth Factor - genetics Heparin-binding EGF-like Growth Factor - metabolism Heparin-binding epidermal growth factor-like growth factor Hepatic satellite cells Internal Medicine Liver Cirrhosis - chemically induced Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver fibrosis Male Mice Mice, Inbred C57BL Mice, Transgenic Transgenic mice
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