First-trimester placental thickness and the risk of preeclampsia or SGA
Abstract Introduction Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the d...
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| Veröffentlicht in: | Placenta (Eastbourne) 2017-09, Vol.57, p.123-128 |
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| creator | Vachon-Marceau, Chantale Demers, Suzanne Markey, Stéphanie Okun, Nan Girard, Mario Kingdom, John Bujold, Emmanuel |
| description | Abstract Introduction Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. Methods Prospective cohort study of women recruited at 11–14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age. Participants were followed until delivery for pregnancy outcomes. Placental measurements of participants who developed preeclampsia and/or delivered SGA neonate (defined as birth weight below 10th percentile) were compared with those who did not using non-parametric statistical analyses. Results We recruited 991 participants at a mean gestational age of 12.7 ± 0.7 weeks of gestation. SGA (n = 52) was associated with reduced 1st trimester placental thickness (median: 0.89 MoM; interquartile (IQ): 0.75–1.02 vs 0.98 MoM; IQ: 0.84–1.15; p 1.2 MoM significantly increasing the risk for preeclampsia (relative risk: 3.6; 95%CI: 1.5–8.6, p |
| doi_str_mv | 10.1016/j.placenta.2017.06.016 |
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We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. Methods Prospective cohort study of women recruited at 11–14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age. Participants were followed until delivery for pregnancy outcomes. Placental measurements of participants who developed preeclampsia and/or delivered SGA neonate (defined as birth weight below 10th percentile) were compared with those who did not using non-parametric statistical analyses. Results We recruited 991 participants at a mean gestational age of 12.7 ± 0.7 weeks of gestation. SGA (n = 52) was associated with reduced 1st trimester placental thickness (median: 0.89 MoM; interquartile (IQ): 0.75–1.02 vs 0.98 MoM; IQ: 0.84–1.15; p < 0.01). Pregnancies that developed preeclampsia (n = 20) tended to have greater placental thickness (median: 1.10 MoM; IQ: 0.93–1.25 vs 0.97 MoM; IQ: 0.84–1.14; p = 0.06) with values > 1.2 MoM significantly increasing the risk for preeclampsia (relative risk: 3.6; 95%CI: 1.5–8.6, p < 0.01). Pregnancies complicated by both SGA and preeclampsia (n = 5) had similar placental thickness in the first-trimester in comparison with uncomplicated pregnancies (median: 1.03 MoM; IQ: 0.89–1.42 vs 0.98 MoM; IQ: 0.84–1.14; p = 0.33) Conclusion First-trimester placental thickness diverges in pregnancies at risk of preeclampsia (increased) or SGA (decreased), but remains within normal values in pregnancies at risk of both conditions, suggesting that the underlying pathologies have some opposing effects on early placental growth. The current findings should be validated in a larger cohort.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2017.06.016</identifier><identifier>PMID: 28864000</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Case-Control Studies ; Female ; Fetal growth ; Fetal Growth Retardation - pathology ; Humans ; Infant, Small for Gestational Age ; Internal Medicine ; Obstetrics and Gynecology ; Placenta ; Placenta - pathology ; Pre-Eclampsia - pathology ; Preeclampsia ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Ultrasound ; Young Adult</subject><ispartof>Placenta (Eastbourne), 2017-09, Vol.57, p.123-128</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-5a8ec22b1367c17e7985b402c0a734f3b7f52c66514458ffe600f717aa96c1c93</citedby><cites>FETCH-LOGICAL-c423t-5a8ec22b1367c17e7985b402c0a734f3b7f52c66514458ffe600f717aa96c1c93</cites><orcidid>0000-0002-6936-4369 ; 0000-0002-0754-4161</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.placenta.2017.06.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28864000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vachon-Marceau, Chantale</creatorcontrib><creatorcontrib>Demers, Suzanne</creatorcontrib><creatorcontrib>Markey, Stéphanie</creatorcontrib><creatorcontrib>Okun, Nan</creatorcontrib><creatorcontrib>Girard, Mario</creatorcontrib><creatorcontrib>Kingdom, John</creatorcontrib><creatorcontrib>Bujold, Emmanuel</creatorcontrib><title>First-trimester placental thickness and the risk of preeclampsia or SGA</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Introduction Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. Methods Prospective cohort study of women recruited at 11–14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age. Participants were followed until delivery for pregnancy outcomes. Placental measurements of participants who developed preeclampsia and/or delivered SGA neonate (defined as birth weight below 10th percentile) were compared with those who did not using non-parametric statistical analyses. Results We recruited 991 participants at a mean gestational age of 12.7 ± 0.7 weeks of gestation. SGA (n = 52) was associated with reduced 1st trimester placental thickness (median: 0.89 MoM; interquartile (IQ): 0.75–1.02 vs 0.98 MoM; IQ: 0.84–1.15; p < 0.01). Pregnancies that developed preeclampsia (n = 20) tended to have greater placental thickness (median: 1.10 MoM; IQ: 0.93–1.25 vs 0.97 MoM; IQ: 0.84–1.14; p = 0.06) with values > 1.2 MoM significantly increasing the risk for preeclampsia (relative risk: 3.6; 95%CI: 1.5–8.6, p < 0.01). Pregnancies complicated by both SGA and preeclampsia (n = 5) had similar placental thickness in the first-trimester in comparison with uncomplicated pregnancies (median: 1.03 MoM; IQ: 0.89–1.42 vs 0.98 MoM; IQ: 0.84–1.14; p = 0.33) Conclusion First-trimester placental thickness diverges in pregnancies at risk of preeclampsia (increased) or SGA (decreased), but remains within normal values in pregnancies at risk of both conditions, suggesting that the underlying pathologies have some opposing effects on early placental growth. The current findings should be validated in a larger cohort.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Fetal growth</subject><subject>Fetal Growth Retardation - pathology</subject><subject>Humans</subject><subject>Infant, Small for Gestational Age</subject><subject>Internal Medicine</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta</subject><subject>Placenta - pathology</subject><subject>Pre-Eclampsia - pathology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Prospective Studies</subject><subject>Ultrasound</subject><subject>Young Adult</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFu2zAMFYYVa9ruFwofd7FHSrJkX4YVxZoVKNBD27OgMDSmxLE9yRnQv5-CNDvs0hPBh8dHvkchrhEqBDRfN9XUe-Jh9pUEtBWYKsMfxAJrJUuFID-KBaBWpQbQ5-IipQ0AtBrlJ3Eum8ZkHBZieRdimss5hh2nmWNxku2L-Veg7cApFX5Y546LGNK2GLtiiszU-92Ugi_GWDwtb67EWef7xJ_f6qV4ufvxfPuzfHhc3t_ePJSkpZrL2jdMUq5QGUto2bZNvdIgCbxVulMr29WSjKlR67rpOjYAnUXrfWsIqVWX4stRd4rj730-2e1CIu57P_C4Tw5bZdAoXWOmmiOV4phS5M5N2aWPrw7BHUJ0G3dy6w4hOjAuw3nw-m3HfrXj9b-xU2qZ8P1I4Oz0T-DoEgUeiNchMs1uPYb3d3z7T4L6MATy_ZZfOW3GfRxyjg5dkg7c0-GVh0-iVaBQgvoLBjOZ2g</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Vachon-Marceau, Chantale</creator><creator>Demers, Suzanne</creator><creator>Markey, Stéphanie</creator><creator>Okun, Nan</creator><creator>Girard, Mario</creator><creator>Kingdom, John</creator><creator>Bujold, Emmanuel</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6936-4369</orcidid><orcidid>https://orcid.org/0000-0002-0754-4161</orcidid></search><sort><creationdate>20170901</creationdate><title>First-trimester placental thickness and the risk of preeclampsia or SGA</title><author>Vachon-Marceau, Chantale ; Demers, Suzanne ; Markey, Stéphanie ; Okun, Nan ; Girard, Mario ; Kingdom, John ; Bujold, Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-5a8ec22b1367c17e7985b402c0a734f3b7f52c66514458ffe600f717aa96c1c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Fetal growth</topic><topic>Fetal Growth Retardation - pathology</topic><topic>Humans</topic><topic>Infant, Small for Gestational Age</topic><topic>Internal Medicine</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta</topic><topic>Placenta - pathology</topic><topic>Pre-Eclampsia - pathology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Prospective Studies</topic><topic>Ultrasound</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vachon-Marceau, Chantale</creatorcontrib><creatorcontrib>Demers, Suzanne</creatorcontrib><creatorcontrib>Markey, Stéphanie</creatorcontrib><creatorcontrib>Okun, Nan</creatorcontrib><creatorcontrib>Girard, Mario</creatorcontrib><creatorcontrib>Kingdom, John</creatorcontrib><creatorcontrib>Bujold, Emmanuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vachon-Marceau, Chantale</au><au>Demers, Suzanne</au><au>Markey, Stéphanie</au><au>Okun, Nan</au><au>Girard, Mario</au><au>Kingdom, John</au><au>Bujold, Emmanuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-trimester placental thickness and the risk of preeclampsia or SGA</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>57</volume><spage>123</spage><epage>128</epage><pages>123-128</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><abstract>Abstract Introduction Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestational-age (SGA) neonate. Methods Prospective cohort study of women recruited at 11–14 weeks gestation. Placental thickness was measured at its apparent center and reported in multiple of median (MoM) adjusted for gestational age. Participants were followed until delivery for pregnancy outcomes. Placental measurements of participants who developed preeclampsia and/or delivered SGA neonate (defined as birth weight below 10th percentile) were compared with those who did not using non-parametric statistical analyses. Results We recruited 991 participants at a mean gestational age of 12.7 ± 0.7 weeks of gestation. SGA (n = 52) was associated with reduced 1st trimester placental thickness (median: 0.89 MoM; interquartile (IQ): 0.75–1.02 vs 0.98 MoM; IQ: 0.84–1.15; p < 0.01). Pregnancies that developed preeclampsia (n = 20) tended to have greater placental thickness (median: 1.10 MoM; IQ: 0.93–1.25 vs 0.97 MoM; IQ: 0.84–1.14; p = 0.06) with values > 1.2 MoM significantly increasing the risk for preeclampsia (relative risk: 3.6; 95%CI: 1.5–8.6, p < 0.01). Pregnancies complicated by both SGA and preeclampsia (n = 5) had similar placental thickness in the first-trimester in comparison with uncomplicated pregnancies (median: 1.03 MoM; IQ: 0.89–1.42 vs 0.98 MoM; IQ: 0.84–1.14; p = 0.33) Conclusion First-trimester placental thickness diverges in pregnancies at risk of preeclampsia (increased) or SGA (decreased), but remains within normal values in pregnancies at risk of both conditions, suggesting that the underlying pathologies have some opposing effects on early placental growth. The current findings should be validated in a larger cohort.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28864000</pmid><doi>10.1016/j.placenta.2017.06.016</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6936-4369</orcidid><orcidid>https://orcid.org/0000-0002-0754-4161</orcidid></addata></record> |
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| subjects | Adolescent Adult Case-Control Studies Female Fetal growth Fetal Growth Retardation - pathology Humans Infant, Small for Gestational Age Internal Medicine Obstetrics and Gynecology Placenta Placenta - pathology Pre-Eclampsia - pathology Preeclampsia Pregnancy Pregnancy Trimester, First Prospective Studies Ultrasound Young Adult |
| title | First-trimester placental thickness and the risk of preeclampsia or SGA |
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