Anti‐apoptosis endothelial cell‐secreted microRNA‐195‐5p promotes pulmonary arterial smooth muscle cell proliferation and migration in pulmonary arterial hypertension

In the pathological mechanism of pulmonary arterial hypertension, the role of apoptosis‐resistant pulmonary microvascular endothelial cells (PVECs/AR) has been emphasized on the pulmonary vascular remodeling. In the present study, we investigated whether PVECs/AR can promote the proliferation and mi...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-02, Vol.119 (2), p.2144-2155
Hauptverfasser:	Zeng, Zhen, Yao, Jun, Li, Yinchuan, Xue, Ying, Zou, Yinghua, Shu, Zhuoling, Jiao, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis apoptosis‐resistant pulmonary endothelial cells Cell culture Cell growth Cell Hypoxia Cell migration Cell Movement Cell Proliferation Cells, Cultured Coculture Techniques Crosstalk Endothelial cells Endothelial Cells - chemistry Endothelial Cells - cytology Humans Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a microRNAs MicroRNAs - secretion Microvasculature miRNA Muscle, Smooth, Vascular - cytology Muscles Myocytes, Smooth Muscle - cytology Paracrine Communication Paracrine signalling pulmonary arterial hypertension Pulmonary Artery Pulmonary hypertension pulmonary vascular remodeling Rats Regulatory sequences Ribonucleic acid RNA Smad7 protein Smad7 Protein - metabolism Smooth muscle Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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