Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice

Infection with the soil bacterium Burkholderia pseudomallei can result in a variety of clinical outcomes, including asymptomatic infection. The initial immune defense mechanisms which might contribute to the various outcomes after environmental contact with B. pseudomallei are largely unknown. We ha...

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Veröffentlicht in:	Infection and Immunity 2006-11, Vol.74 (11), p.6300-6309
Hauptverfasser:	Breitbach, Katrin, Klocke, Sonja, Tschernig, Thomas, Rooijen, Nico van, Baumann, Ulrich, Steinmetz, Ivo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Bacteriology Biological and medical sciences Burkholderia pseudomallei Cells, Cultured Female Fundamental and applied biological sciences. Psychology Host Response and Inflammation Human bacterial diseases Infectious diseases Macrophages - enzymology Macrophages - microbiology Medical sciences Melioidosis Melioidosis - enzymology Melioidosis - immunology Melioidosis - microbiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microbiology Miscellaneous NADPH Oxidases - deficiency NADPH Oxidases - genetics NADPH Oxidases - physiology Nitric Oxide Synthase Type II - deficiency Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - physiology Tropical bacterial diseases
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