A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade

An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination...

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Veröffentlicht in:Organic letters 2017-09, Vol.19 (18), p.4968-4971
Hauptverfasser: Huang, Chaoqian, Zeng, Yu, Cheng, Huayu, Hu, Anjing, Liu, Lu, Xiao, Yuanjing, Zhang, Junliang
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container_end_page 4971
container_issue 18
container_start_page 4968
container_title Organic letters
container_volume 19
creator Huang, Chaoqian
Zeng, Yu
Cheng, Huayu
Hu, Anjing
Liu, Lu
Xiao, Yuanjing
Zhang, Junliang
description An easy two-step, one-pot synthesis of halogenated trifluoromethylated pyrroles is realized by sequential intermolecular hydroamination reaction of 2-trifluoromethyl-1,3-enynes with aliphatic primary amines under mild reaction conditions, and NXS mediated oxidative cyclization of the hydroamination product. The salient features of this method include mild conditions, readily available starting materials, general substrate scope, high efficiency and synthetic utility of the products.
doi_str_mv 10.1021/acs.orglett.7b02427
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title A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X = Br, I) Triggered Cascade
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