Transducer of Regulated CREB-Binding Proteins (TORCs) Induce PGC-1α Transcription and Mitochondrial Biogenesis in Muscle Cells

PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α) is a master regulator of mitochondrial biogenesis and plays an important role in several other aspects of energy metabolism. To identify upstream regulators of PGC-1α gene transcription, 10,000 human full-length cDNAs were screened...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-09, Vol.103 (39), p.14379-14384
Hauptverfasser:	Wu, Zhidan, Huang, Xueming, Feng, Yajun, Handschin, Christoph, Feng, Yan, Gullicksen, P. Scott, Bare, Olivia, Labow, Mark, Spiegelman, Bruce, Stevenson, Susan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Biological Sciences Cell respiration Cells Complementary DNA Genes HeLa cells Messenger RNA Muscle cells Muscle fibers Torcs
Online-Zugang:	Volltext
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