Low IDL-B and high LDL-1 subfraction levels in serum of ALS patients

Converging evidence highlights that lipid metabolism plays a key role in ALS pathophysiology. Dyslipidemia has been described in ALS patients and may be protective but peripheral lipoprotein subclasses have never been studied. We collected sera from 30 ALS patients and 30 gender and age-matched cont...

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Veröffentlicht in:Journal of the neurological sciences 2017-09, Vol.380, p.124-127
Hauptverfasser: Delaye, J.B., Patin, F., Piver, E., Bruno, C., Vasse, M., Vourc'h, P., Andres, C.R., Corcia, P., Blasco, H.
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Sprache:eng
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Zusammenfassung:Converging evidence highlights that lipid metabolism plays a key role in ALS pathophysiology. Dyslipidemia has been described in ALS patients and may be protective but peripheral lipoprotein subclasses have never been studied. We collected sera from 30 ALS patients and 30 gender and age-matched controls. We analyzed 11 distinct lipoprotein subclasses by linear polyacrylamide gel electrophoresis (Lipoprint, Quantimetrix Corporation, USA). We also measured lipoprotein (a), apolipoprotein B, and apolipoprotein E levels. ALS patients had significant higher total cholesterol, HDL-cholesterol, and LDL-cholesterol levels than controls (p
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2017.07.019