Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging
The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other. We compared the clinical parameters of 300 elderly patients with ischemic stroke, a...
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| Veröffentlicht in: | Journal of the neurological sciences 2017-09, Vol.380, p.85-91 |
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| container_title | Journal of the neurological sciences |
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| creator | Fukui, Sayato Imazeki, Ryoko Amano, Yu Kudo, Yousuke Amari, Kazumitsu Yamamoto, Masahiro Todoroki, Kikue Ikeya, Yoshimori Okazaki, Takashi Yanagimachi, Noriharu Shizuma, Toru Fukuyama, Naoto Johkura, Ken Mori, Hidezo |
| description | The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other.
We compared the clinical parameters of 300 elderly patients with ischemic stroke, age 65-98years, to 100 age-matched control patients.
Comparison by parametric test and logistic regression analysis between all 300 and 100 control patients showed higher systolic and diastolic blood pressures (p |
| doi_str_mv | 10.1016/j.jns.2017.07.001 |
| format | Article |
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We compared the clinical parameters of 300 elderly patients with ischemic stroke, age 65-98years, to 100 age-matched control patients.
Comparison by parametric test and logistic regression analysis between all 300 and 100 control patients showed higher systolic and diastolic blood pressures (p<0.001, p=0.03), lower estimated glomerular filtration rate (eGFR) (p=0.01), larger cardiothoracic ratio (CTR) (p<0.001), smoking (p<0.01) and possibly poor adherence to anti-hypertensive agents in the ischemic stroke patients (p<0.001). Comparisons among three types (n=100 for each) showed the highest atheromatous risk factors for ATI to be hemoglobin A1c (p=0.01) and low-density lipoprotein (p<0.001) and for CEI to be largest cardiac load, indicated by largest left atrial dimension (p<0.001), and CTR (p<0.001). Triglyceride level was found to be a borderline risk factor for LI (p=0.054). Comparison between those aged <74 versus ≥75years (n=150 for each) showed a lower eGFR (p=0.02) and larger right atrial dimension (p<0.001) in patients ≥75.
The risk factors were quite different among the subtypes and aging.]]></description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2017.07.001</identifier><identifier>PMID: 28870596</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Brain Ischemia - diagnostic imaging ; Brain Ischemia - drug therapy ; Brain Ischemia - epidemiology ; Brain Ischemia - physiopathology ; Female ; Humans ; Logistic Models ; Male ; Retrospective Studies ; Risk Factors ; Stroke - diagnostic imaging ; Stroke - drug therapy ; Stroke - epidemiology ; Stroke - physiopathology</subject><ispartof>Journal of the neurological sciences, 2017-09, Vol.380, p.85-91</ispartof><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-d62ae9fadece58d7888956f780ae94a76572e1ebd2f8f86c9f6e619fb64984e3</citedby><cites>FETCH-LOGICAL-c367t-d62ae9fadece58d7888956f780ae94a76572e1ebd2f8f86c9f6e619fb64984e3</cites><orcidid>0000-0002-1325-3264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28870596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukui, Sayato</creatorcontrib><creatorcontrib>Imazeki, Ryoko</creatorcontrib><creatorcontrib>Amano, Yu</creatorcontrib><creatorcontrib>Kudo, Yousuke</creatorcontrib><creatorcontrib>Amari, Kazumitsu</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Todoroki, Kikue</creatorcontrib><creatorcontrib>Ikeya, Yoshimori</creatorcontrib><creatorcontrib>Okazaki, Takashi</creatorcontrib><creatorcontrib>Yanagimachi, Noriharu</creatorcontrib><creatorcontrib>Shizuma, Toru</creatorcontrib><creatorcontrib>Fukuyama, Naoto</creatorcontrib><creatorcontrib>Johkura, Ken</creatorcontrib><creatorcontrib>Mori, Hidezo</creatorcontrib><title>Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description><![CDATA[The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other.
We compared the clinical parameters of 300 elderly patients with ischemic stroke, age 65-98years, to 100 age-matched control patients.
Comparison by parametric test and logistic regression analysis between all 300 and 100 control patients showed higher systolic and diastolic blood pressures (p<0.001, p=0.03), lower estimated glomerular filtration rate (eGFR) (p=0.01), larger cardiothoracic ratio (CTR) (p<0.001), smoking (p<0.01) and possibly poor adherence to anti-hypertensive agents in the ischemic stroke patients (p<0.001). Comparisons among three types (n=100 for each) showed the highest atheromatous risk factors for ATI to be hemoglobin A1c (p=0.01) and low-density lipoprotein (p<0.001) and for CEI to be largest cardiac load, indicated by largest left atrial dimension (p<0.001), and CTR (p<0.001). Triglyceride level was found to be a borderline risk factor for LI (p=0.054). Comparison between those aged <74 versus ≥75years (n=150 for each) showed a lower eGFR (p=0.02) and larger right atrial dimension (p<0.001) in patients ≥75.
The risk factors were quite different among the subtypes and aging.]]></description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - drug therapy</subject><subject>Stroke - epidemiology</subject><subject>Stroke - physiopathology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUMtOwzAQtBCIlsIHcEE-ckmwk8Z2uKHylCpx6YGb5Tjr4jSJg50K9e9x1cIFaaSVdmdmR4PQNSUpJZTdNWnThzQjlKckgtATNKWCi6QQIj9FU0KyLCko-ZigixAaQggTojxHk0wIToqSTdH3wnWd67HqaxwG0NZYjb0NG2yUHp0P2DiPbdCf0MVLGL3bALY9hrYG3-7u8aM1Bjz0GgKuVIAaR7txNwB25p9w_0atbb--RGdGtQGujnOGVs9Pq8Vrsnx_eVs8LBOdMz4mNcsUlEbVoKEQNRcxf8EMFySu54qzgmdAoaozI4xgujQMGC1NxealmEM-Q7cH28G7ry2EUXYxErSt6sFtg6RlXghaUJ5HKj1QtXcheDBy8LZTficpkfu6ZSNj3XJftyQRhEbNzdF-W3VQ_yl--81_ACPvflY</recordid><startdate>20170915</startdate><enddate>20170915</enddate><creator>Fukui, Sayato</creator><creator>Imazeki, Ryoko</creator><creator>Amano, Yu</creator><creator>Kudo, Yousuke</creator><creator>Amari, Kazumitsu</creator><creator>Yamamoto, Masahiro</creator><creator>Todoroki, Kikue</creator><creator>Ikeya, Yoshimori</creator><creator>Okazaki, Takashi</creator><creator>Yanagimachi, Noriharu</creator><creator>Shizuma, Toru</creator><creator>Fukuyama, Naoto</creator><creator>Johkura, Ken</creator><creator>Mori, Hidezo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1325-3264</orcidid></search><sort><creationdate>20170915</creationdate><title>Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging</title><author>Fukui, Sayato ; Imazeki, Ryoko ; Amano, Yu ; Kudo, Yousuke ; Amari, Kazumitsu ; Yamamoto, Masahiro ; Todoroki, Kikue ; Ikeya, Yoshimori ; Okazaki, Takashi ; Yanagimachi, Noriharu ; Shizuma, Toru ; Fukuyama, Naoto ; Johkura, Ken ; Mori, Hidezo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-d62ae9fadece58d7888956f780ae94a76572e1ebd2f8f86c9f6e619fb64984e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - drug therapy</topic><topic>Stroke - epidemiology</topic><topic>Stroke - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukui, Sayato</creatorcontrib><creatorcontrib>Imazeki, Ryoko</creatorcontrib><creatorcontrib>Amano, Yu</creatorcontrib><creatorcontrib>Kudo, Yousuke</creatorcontrib><creatorcontrib>Amari, Kazumitsu</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Todoroki, Kikue</creatorcontrib><creatorcontrib>Ikeya, Yoshimori</creatorcontrib><creatorcontrib>Okazaki, Takashi</creatorcontrib><creatorcontrib>Yanagimachi, Noriharu</creatorcontrib><creatorcontrib>Shizuma, Toru</creatorcontrib><creatorcontrib>Fukuyama, Naoto</creatorcontrib><creatorcontrib>Johkura, Ken</creatorcontrib><creatorcontrib>Mori, Hidezo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukui, Sayato</au><au>Imazeki, Ryoko</au><au>Amano, Yu</au><au>Kudo, Yousuke</au><au>Amari, Kazumitsu</au><au>Yamamoto, Masahiro</au><au>Todoroki, Kikue</au><au>Ikeya, Yoshimori</au><au>Okazaki, Takashi</au><au>Yanagimachi, Noriharu</au><au>Shizuma, Toru</au><au>Fukuyama, Naoto</au><au>Johkura, Ken</au><au>Mori, Hidezo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2017-09-15</date><risdate>2017</risdate><volume>380</volume><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract><![CDATA[The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other.
We compared the clinical parameters of 300 elderly patients with ischemic stroke, age 65-98years, to 100 age-matched control patients.
Comparison by parametric test and logistic regression analysis between all 300 and 100 control patients showed higher systolic and diastolic blood pressures (p<0.001, p=0.03), lower estimated glomerular filtration rate (eGFR) (p=0.01), larger cardiothoracic ratio (CTR) (p<0.001), smoking (p<0.01) and possibly poor adherence to anti-hypertensive agents in the ischemic stroke patients (p<0.001). Comparisons among three types (n=100 for each) showed the highest atheromatous risk factors for ATI to be hemoglobin A1c (p=0.01) and low-density lipoprotein (p<0.001) and for CEI to be largest cardiac load, indicated by largest left atrial dimension (p<0.001), and CTR (p<0.001). Triglyceride level was found to be a borderline risk factor for LI (p=0.054). Comparison between those aged <74 versus ≥75years (n=150 for each) showed a lower eGFR (p=0.02) and larger right atrial dimension (p<0.001) in patients ≥75.
The risk factors were quite different among the subtypes and aging.]]></abstract><cop>Netherlands</cop><pmid>28870596</pmid><doi>10.1016/j.jns.2017.07.001</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1325-3264</orcidid></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Brain Ischemia - diagnostic imaging Brain Ischemia - drug therapy Brain Ischemia - epidemiology Brain Ischemia - physiopathology Female Humans Logistic Models Male Retrospective Studies Risk Factors Stroke - diagnostic imaging Stroke - drug therapy Stroke - epidemiology Stroke - physiopathology |
| title | Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging |
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