Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells

Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We...

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Veröffentlicht in:	Diabetes research and clinical practice 2017-11, Vol.133, p.10-12
Hauptverfasser:	Iijima, Toshie, Kato, Kanako, Jojima, Teruo, Tomotsune, Takanori, Fukushima, Maiko, Suzuki, Kunihiro, Aso, Yoshimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged CD4 Antigens - immunology CD8 Antigens - immunology Diabetes Mellitus, Type 1 - metabolism Female Humans Male Programmed Cell Death 1 Receptor - immunology T-Lymphocytes, Regulatory - immunology
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container_title	Diabetes research and clinical practice
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creator	Iijima, Toshie Kato, Kanako Jojima, Teruo Tomotsune, Takanori Fukushima, Maiko Suzuki, Kunihiro Aso, Yoshimasa
description	Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D.
doi_str_mv	10.1016/j.diabres.2017.07.036
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subjects	Aged CD4 Antigens - immunology CD8 Antigens - immunology Diabetes Mellitus, Type 1 - metabolism Female Humans Male Programmed Cell Death 1 Receptor - immunology T-Lymphocytes, Regulatory - immunology
title	Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells
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