Communicate or Die - A Model for HPV+ and HPV- CSCs and Their Interactions with SDF-1α
Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1α (SDF-1α) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1α on HPV+/H...
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| Veröffentlicht in: | Anticancer research 2017-09, Vol.37 (9), p.4827-4836 |
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| container_title | Anticancer research |
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| creator | Jungbauer, Frederic Aderhold, Christoph Birk, Richard Hoermann, Karl Kramer, Benedikt Kuhlin, Beatrice Thorn, Carsten Umbreit, Claudia Lammert, Anne |
| description | Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1α (SDF-1α) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1α on HPV+/HPV- SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs.
We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1α on proliferation, morphology and migration of HPV+/HPV- SCCs.
HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1α. HPV+ SCCs rested nearly unaffected by SDF-1α.
Weakened reaction to SDF-1α in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents. |
| doi_str_mv | 10.21873/anticanres.11890 |
| format | Article |
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We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1α on proliferation, morphology and migration of HPV+/HPV- SCCs.
HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1α. HPV+ SCCs rested nearly unaffected by SDF-1α.
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We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1α on proliferation, morphology and migration of HPV+/HPV- SCCs.
HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1α. HPV+ SCCs rested nearly unaffected by SDF-1α.
Weakened reaction to SDF-1α in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents.</description><subject>Cell Communication - drug effects</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemokine CXCL12 - pharmacology</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Models, Biological</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Papillomaviridae - physiology</subject><subject>Receptors, CXCR4 - metabolism</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1OwjAYhhujEUQvwBPTQxMz_NrSdT00Q4QEowmoh0vXfgszbMN2xHhZ3ojXJALq0feT930OHkLOGfQ5S5S4NnVbWlN7DH3GEg0HpMuUZpGSAg5JF7iESAHIDjkJ4RUgjnUijkmHJ4kCDbxLXtKmqtb1htIibTwdlkgjekPvG4dLWmw-48fnK2pq97NENJ2lYXvNF1h6Oqlb9Ma2ZVMH-l62CzobjiL29XlKjgqzDHi2nz3yNLqdp-No-nA3SW-mkeVSQ-SkY1bjoEgkx8LGOMjBWu1izkSMubDcgSq0MqCURZC545BzCwPlTG6FET1yueOufPO2xtBmVRksLpemxmYdMqaFTNhASNhE2S5qfROCxyJb-bIy_iNjkG19Zv8-s63PTedij1_nFbq_xq9A8Q3TjnHh</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Jungbauer, Frederic</creator><creator>Aderhold, Christoph</creator><creator>Birk, Richard</creator><creator>Hoermann, Karl</creator><creator>Kramer, Benedikt</creator><creator>Kuhlin, Beatrice</creator><creator>Thorn, Carsten</creator><creator>Umbreit, Claudia</creator><creator>Lammert, Anne</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Communicate or Die - A Model for HPV+ and HPV- CSCs and Their Interactions with SDF-1α</title><author>Jungbauer, Frederic ; 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Stromal cell-derived factor-1α (SDF-1α) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1α on HPV+/HPV- SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs.
We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1α on proliferation, morphology and migration of HPV+/HPV- SCCs.
HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1α. HPV+ SCCs rested nearly unaffected by SDF-1α.
Weakened reaction to SDF-1α in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents.</abstract><cop>Greece</cop><pmid>28870902</pmid><doi>10.21873/anticanres.11890</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Cell Communication - drug effects Cell Death - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chemokine CXCL12 - pharmacology Fluorescent Antibody Technique Humans Hyaluronan Receptors - metabolism Models, Biological Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Papillomaviridae - physiology Receptors, CXCR4 - metabolism |
| title | Communicate or Die - A Model for HPV+ and HPV- CSCs and Their Interactions with SDF-1α |
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