Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2

Telomeric repeat factor 2 (known as TRF2 or TERF2) is a key component of telomere protection protein complex named as Shelterin. TRF2 helps the folding of telomere to form T-loop structure and the suppression of ATM-dependent DNA damage response activation. TRF2 has been recognized as a potentially...

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Veröffentlicht in:	Biochimica et biophysica acta. Proteins and proteomics 2017-11, Vol.1865 (11), p.1372-1382
Hauptverfasser:	Wang, Mingxue, Cao, Jiaojiao, Zhu, Jian-Yong, Qiu, Jun, Zhang, Yan, Shu, Bing, Ou, Tian-Miao, Tan, Jia-Heng, Gu, Lian-Quan, Huang, Zhi-Shu, Yin, Sheng, Li, Ding
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Binding Sites Cell Cycle Checkpoints - drug effects Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Curcusone C Diterpenes - isolation & purification Diterpenes - pharmacology DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Dose-Response Relationship, Drug Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation, Neoplastic HeLa Cells Humans Organ Specificity Protein Binding Recombinant Proteins - genetics Recombinant Proteins - metabolism Shelterin Signal Transduction Telomere Telomere - chemistry Telomere - drug effects Telomeric Repeat Binding Protein 1 - genetics Telomeric Repeat Binding Protein 1 - metabolism Telomeric Repeat Binding Protein 2 - antagonists & inhibitors Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism TERF2 TRF2
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