Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants
One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2017-09, Vol.37 (9), p.4759-4766 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4766 |
|---|---|
| container_issue | 9 |
| container_start_page | 4759 |
| container_title | Anticancer research |
| container_volume | 37 |
| creator | Carini, Francesco Mazzola, Margherita Rappa, Francesca Jurjus, Abdo Geagea, Alice Gerges Al Kattar, Sahar Bou-Assi, Tarek Jurjus, Rosalyn Damiani, Provvidenza Leone, Angelo Tomasello, Giovanni |
| description | One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models. |
| doi_str_mv | 10.21873/anticanres.11882 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1935814119</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1935814119</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-a073d7a86500c251e9966bc2e79a48f4a055504bb9437502b64dbc2d0fa38e13</originalsourceid><addsrcrecordid>eNpFkE1LwzAYx4Mobk4_gBfp0UvnkyZpEm-j8w0GA929pOlTqXTJTDrRb2_dpp7-h_8b_Ai5pDDNqJLsxri-tcYFjFNKlcqOyJhKTVMpGByTMWQCUgkgRuQsxjeAPNeKnZJRppQEpfmYzAvf-YC2N11SmGBb51_RYWzjbfLsO0x8kyw_29r07QcmL_1wFRPj6mQ2XPsfw_XxnJw0pot4cdAJWd3frYrHdLF8eCpmi9QyzvvUgGS1NCoXADYTFLXO88pmKLXhquEGhBDAq0pzJgVkVc7rwa6hMUwhZRNyvZ_dBP--xdiX6zZa7Drj0G9jSTUTinI66ITQfdQGH2PAptyEdm3CV0mh3LEr_9mVO3ZD5-owv63WWP81fmGxb5P4bKA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1935814119</pqid></control><display><type>article</type><title>Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Carini, Francesco ; Mazzola, Margherita ; Rappa, Francesca ; Jurjus, Abdo ; Geagea, Alice Gerges ; Al Kattar, Sahar ; Bou-Assi, Tarek ; Jurjus, Rosalyn ; Damiani, Provvidenza ; Leone, Angelo ; Tomasello, Giovanni</creator><creatorcontrib>Carini, Francesco ; Mazzola, Margherita ; Rappa, Francesca ; Jurjus, Abdo ; Geagea, Alice Gerges ; Al Kattar, Sahar ; Bou-Assi, Tarek ; Jurjus, Rosalyn ; Damiani, Provvidenza ; Leone, Angelo ; Tomasello, Giovanni</creatorcontrib><description>One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.11882</identifier><identifier>PMID: 28870894</identifier><language>eng</language><publisher>Greece</publisher><subject>Animals ; Antioxidants - pharmacology ; Carcinogenesis - drug effects ; Carcinogenesis - pathology ; Colorectal Neoplasms - pathology ; Humans ; Oxidative Stress - drug effects ; Reactive Oxygen Species - metabolism</subject><ispartof>Anticancer research, 2017-09, Vol.37 (9), p.4759-4766</ispartof><rights>Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-a073d7a86500c251e9966bc2e79a48f4a055504bb9437502b64dbc2d0fa38e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28870894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carini, Francesco</creatorcontrib><creatorcontrib>Mazzola, Margherita</creatorcontrib><creatorcontrib>Rappa, Francesca</creatorcontrib><creatorcontrib>Jurjus, Abdo</creatorcontrib><creatorcontrib>Geagea, Alice Gerges</creatorcontrib><creatorcontrib>Al Kattar, Sahar</creatorcontrib><creatorcontrib>Bou-Assi, Tarek</creatorcontrib><creatorcontrib>Jurjus, Rosalyn</creatorcontrib><creatorcontrib>Damiani, Provvidenza</creatorcontrib><creatorcontrib>Leone, Angelo</creatorcontrib><creatorcontrib>Tomasello, Giovanni</creatorcontrib><title>Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Carcinogenesis - drug effects</subject><subject>Carcinogenesis - pathology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Humans</subject><subject>Oxidative Stress - drug effects</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LwzAYx4Mobk4_gBfp0UvnkyZpEm-j8w0GA929pOlTqXTJTDrRb2_dpp7-h_8b_Ai5pDDNqJLsxri-tcYFjFNKlcqOyJhKTVMpGByTMWQCUgkgRuQsxjeAPNeKnZJRppQEpfmYzAvf-YC2N11SmGBb51_RYWzjbfLsO0x8kyw_29r07QcmL_1wFRPj6mQ2XPsfw_XxnJw0pot4cdAJWd3frYrHdLF8eCpmi9QyzvvUgGS1NCoXADYTFLXO88pmKLXhquEGhBDAq0pzJgVkVc7rwa6hMUwhZRNyvZ_dBP--xdiX6zZa7Drj0G9jSTUTinI66ITQfdQGH2PAptyEdm3CV0mh3LEr_9mVO3ZD5-owv63WWP81fmGxb5P4bKA</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Carini, Francesco</creator><creator>Mazzola, Margherita</creator><creator>Rappa, Francesca</creator><creator>Jurjus, Abdo</creator><creator>Geagea, Alice Gerges</creator><creator>Al Kattar, Sahar</creator><creator>Bou-Assi, Tarek</creator><creator>Jurjus, Rosalyn</creator><creator>Damiani, Provvidenza</creator><creator>Leone, Angelo</creator><creator>Tomasello, Giovanni</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants</title><author>Carini, Francesco ; Mazzola, Margherita ; Rappa, Francesca ; Jurjus, Abdo ; Geagea, Alice Gerges ; Al Kattar, Sahar ; Bou-Assi, Tarek ; Jurjus, Rosalyn ; Damiani, Provvidenza ; Leone, Angelo ; Tomasello, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-a073d7a86500c251e9966bc2e79a48f4a055504bb9437502b64dbc2d0fa38e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Carcinogenesis - drug effects</topic><topic>Carcinogenesis - pathology</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Humans</topic><topic>Oxidative Stress - drug effects</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carini, Francesco</creatorcontrib><creatorcontrib>Mazzola, Margherita</creatorcontrib><creatorcontrib>Rappa, Francesca</creatorcontrib><creatorcontrib>Jurjus, Abdo</creatorcontrib><creatorcontrib>Geagea, Alice Gerges</creatorcontrib><creatorcontrib>Al Kattar, Sahar</creatorcontrib><creatorcontrib>Bou-Assi, Tarek</creatorcontrib><creatorcontrib>Jurjus, Rosalyn</creatorcontrib><creatorcontrib>Damiani, Provvidenza</creatorcontrib><creatorcontrib>Leone, Angelo</creatorcontrib><creatorcontrib>Tomasello, Giovanni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carini, Francesco</au><au>Mazzola, Margherita</au><au>Rappa, Francesca</au><au>Jurjus, Abdo</au><au>Geagea, Alice Gerges</au><au>Al Kattar, Sahar</au><au>Bou-Assi, Tarek</au><au>Jurjus, Rosalyn</au><au>Damiani, Provvidenza</au><au>Leone, Angelo</au><au>Tomasello, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>37</volume><issue>9</issue><spage>4759</spage><epage>4766</epage><pages>4759-4766</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models.</abstract><cop>Greece</cop><pmid>28870894</pmid><doi>10.21873/anticanres.11882</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2017-09, Vol.37 (9), p.4759-4766 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1935814119 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antioxidants - pharmacology Carcinogenesis - drug effects Carcinogenesis - pathology Colorectal Neoplasms - pathology Humans Oxidative Stress - drug effects Reactive Oxygen Species - metabolism |
| title | Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T12%3A46%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Colorectal%20Carcinogenesis:%20Role%20of%20Oxidative%20Stress%20and%20Antioxidants&rft.jtitle=Anticancer%20research&rft.au=Carini,%20Francesco&rft.date=2017-09-01&rft.volume=37&rft.issue=9&rft.spage=4759&rft.epage=4766&rft.pages=4759-4766&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/10.21873/anticanres.11882&rft_dat=%3Cproquest_cross%3E1935814119%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1935814119&rft_id=info:pmid/28870894&rfr_iscdi=true |