Age‐specific infectious period shapes dynamics of pneumonia in bighorn sheep
Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, ye...
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| Veröffentlicht in: | Ecology letters 2017-10, Vol.20 (10), p.1325-1336 |
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| creator | Plowright, Raina K. Manlove, Kezia R. Besser, Thomas E. Páez, David J. Andrews, Kimberly R. Matthews, Patrick E. Waits, Lisette P. Hudson, Peter J. Cassirer, E. Frances Leo, Giulio De |
| description | Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free‐ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age‐structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation. |
| doi_str_mv | 10.1111/ele.12829 |
| format | Article |
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Frances ; Leo, Giulio De</creator><creatorcontrib>Plowright, Raina K. ; Manlove, Kezia R. ; Besser, Thomas E. ; Páez, David J. ; Andrews, Kimberly R. ; Matthews, Patrick E. ; Waits, Lisette P. ; Hudson, Peter J. ; Cassirer, E. Frances ; Leo, Giulio De</creatorcontrib><description>Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free‐ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age‐structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation.</description><identifier>ISSN: 1461-023X</identifier><identifier>EISSN: 1461-0248</identifier><identifier>DOI: 10.1111/ele.12829</identifier><identifier>PMID: 28871636</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Age composition ; Animal diseases ; Animals ; Animals, Wild ; bighorn sheep ; disease dynamics ; Disease transmission ; Dynamics ; feedback mechanism ; Infections ; Infectious diseases ; Initial conditions ; Livestock ; Mycoplasma ovipneumoniae ; Mycoplasma pneumoniae ; Ovis canadensis ; pathogen persistence ; persistent carriage ; Pneumonia ; Pneumonia, Mycoplasma - veterinary ; Public health ; Sheep ; Sheep Diseases - epidemiology ; Sheep, Bighorn ; supershedder ; superspreader ; Wildlife ; Wildlife conservation ; wildlife health</subject><ispartof>Ecology letters, 2017-10, Vol.20 (10), p.1325-1336</ispartof><rights>2017 John Wiley & Sons Ltd/CNRS</rights><rights>2017 John Wiley & Sons Ltd/CNRS.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd/CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-4ca716f6d61f92f405964499b3bdeba081d8a5dfb6fb484b9d452a16f3c3d8273</citedby><cites>FETCH-LOGICAL-c3889-4ca716f6d61f92f405964499b3bdeba081d8a5dfb6fb484b9d452a16f3c3d8273</cites><orcidid>0000-0002-3338-6590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fele.12829$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fele.12829$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28871636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plowright, Raina K.</creatorcontrib><creatorcontrib>Manlove, Kezia R.</creatorcontrib><creatorcontrib>Besser, Thomas E.</creatorcontrib><creatorcontrib>Páez, David J.</creatorcontrib><creatorcontrib>Andrews, Kimberly R.</creatorcontrib><creatorcontrib>Matthews, Patrick E.</creatorcontrib><creatorcontrib>Waits, Lisette P.</creatorcontrib><creatorcontrib>Hudson, Peter J.</creatorcontrib><creatorcontrib>Cassirer, E. Frances</creatorcontrib><creatorcontrib>Leo, Giulio De</creatorcontrib><title>Age‐specific infectious period shapes dynamics of pneumonia in bighorn sheep</title><title>Ecology letters</title><addtitle>Ecol Lett</addtitle><description>Superspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free‐ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age‐structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation.</description><subject>Age composition</subject><subject>Animal diseases</subject><subject>Animals</subject><subject>Animals, Wild</subject><subject>bighorn sheep</subject><subject>disease dynamics</subject><subject>Disease transmission</subject><subject>Dynamics</subject><subject>feedback mechanism</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Initial conditions</subject><subject>Livestock</subject><subject>Mycoplasma ovipneumoniae</subject><subject>Mycoplasma pneumoniae</subject><subject>Ovis canadensis</subject><subject>pathogen persistence</subject><subject>persistent carriage</subject><subject>Pneumonia</subject><subject>Pneumonia, Mycoplasma - veterinary</subject><subject>Public health</subject><subject>Sheep</subject><subject>Sheep Diseases - epidemiology</subject><subject>Sheep, Bighorn</subject><subject>supershedder</subject><subject>superspreader</subject><subject>Wildlife</subject><subject>Wildlife conservation</subject><subject>wildlife health</subject><issn>1461-023X</issn><issn>1461-0248</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqUw8AIoEgsMobHjJPZYVeVHqmABiS1y7OvWVRKHuBHqxiPwjDwJLikdkPByPZx77qcPoXMc3WD_xlDCDSaM8AM0xDTFYUQoO9z_49cBOnFuFUWY8AwfowFhLMNpnA7R42QBXx-frgFptJGBqTXItbGdCxpojVWBW4oGXKA2taiMdIHVQVNDV9naCI8HhVksbVt7DqA5RUdalA7OdnOEXm5nz9P7cP509zCdzEMZM8ZDKoW_r1OVYs2JplHCU0o5L-JCQSEihhUTidJFqgvKaMEVTYjwG7GMFSNZPEJXvbdp7VsHbp1XxkkoS1GDz55jHicMk4Rgj17-QVe2a2ufbkvxzOdJtsLrnpKtda4FnTetqUS7yXGUb0vOfcn5T8mevdgZu6ICtSd_W_XAuAfeTQmb_035bD7rld96roZv</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Plowright, Raina K.</creator><creator>Manlove, Kezia R.</creator><creator>Besser, Thomas E.</creator><creator>Páez, David J.</creator><creator>Andrews, Kimberly R.</creator><creator>Matthews, Patrick E.</creator><creator>Waits, Lisette P.</creator><creator>Hudson, Peter J.</creator><creator>Cassirer, E. Frances</creator><creator>Leo, Giulio De</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7SS</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3338-6590</orcidid></search><sort><creationdate>201710</creationdate><title>Age‐specific infectious period shapes dynamics of pneumonia in bighorn sheep</title><author>Plowright, Raina K. ; Manlove, Kezia R. ; Besser, Thomas E. ; Páez, David J. ; Andrews, Kimberly R. ; Matthews, Patrick E. ; Waits, Lisette P. ; Hudson, Peter J. ; Cassirer, E. 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Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free‐ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age‐structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>28871636</pmid><doi>10.1111/ele.12829</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3338-6590</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age composition Animal diseases Animals Animals, Wild bighorn sheep disease dynamics Disease transmission Dynamics feedback mechanism Infections Infectious diseases Initial conditions Livestock Mycoplasma ovipneumoniae Mycoplasma pneumoniae Ovis canadensis pathogen persistence persistent carriage Pneumonia Pneumonia, Mycoplasma - veterinary Public health Sheep Sheep Diseases - epidemiology Sheep, Bighorn supershedder superspreader Wildlife Wildlife conservation wildlife health |
| title | Age‐specific infectious period shapes dynamics of pneumonia in bighorn sheep |
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