Increased Pancreatic {beta}-Cell Proliferation Mediated by CREB Binding Protein Gene Activation

The cyclic AMP (cAMP) signaling pathway is central in {beta}-cell gene expression and function. In the nucleus, protein kinase A (PKA) phosphorylates CREB, resulting in recruitment of the transcriptional coactivators p300 and CREB binding protein (CBP). CBP, but not p300, is phosphorylated at serine...

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Veröffentlicht in:	Molecular and cellular biology 2006-10, Vol.26 (20), p.7747-7759
Hauptverfasser:	Hussain, Mehboob A, Porras, Delia L, Rowe, Matthew H, West, Jason R, Song, Woo-Jin, Schreiber, Weston E, Wondisford, Fredric E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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