Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma

DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregu...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/09/01, Vol.40(9), pp.1416-1422
Hauptverfasser:	Youm, Jihyun, Lee, Hyunyong, Chang, Hwan Bong, Jeon, Jihyun, Yoon, Mi Hee, Woo, Ji Young, Choi, Min-Soo, Hwang, Yunha, Seong, Seungkyoo, Na, Kyuheum, Yoon, Joobyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	airway inflammation allergy Animals Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - pharmacology Asthma Asthma - chemically induced Asthma - pathology Cytokines Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytokines - metabolism Down-Regulation - drug effects Epithelium Ethanol Female High-performance liquid chromatography Hypersensitivity Inflammation Justicia procumbens justicidin Liquid chromatography Lung - pathology Lymphocytes T Mice Mice, Inbred BALB C Ovalbumin Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - prevention & control Respiratory Mucosa - drug effects Respiratory Mucosa - pathology Respiratory tract Respiratory tract diseases Rodents Spleen Spleen - cytology Spleen - metabolism Splenocytes T helper 2 (Th2) cytokine Th2 Cells - drug effects Th2 Cells - metabolism
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