Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma
DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregu...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2017/09/01, Vol.40(9), pp.1416-1422 |
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| creator | Youm, Jihyun Lee, Hyunyong Chang, Hwan Bong Jeon, Jihyun Yoon, Mi Hee Woo, Ji Young Choi, Min-Soo Hwang, Yunha Seong, Seungkyoo Na, Kyuheum Yoon, Joobyoung |
| description | DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregulating pulmonary infiltration of differential inflammatory cells and Th2 cytokines more than a decoction or ethanol extract of J. procumbens did in a mouse asthma model. DW2008 also significantly inhibited airway hyperresponsiveness and reduced the thickness of the airway epithelium. HPLC analysis showed that the major peaks (justicidin A and B) of DW2008 were higher than those of the other extracts. Justicidin A and B significantly suppressed Th2 cytokine levels in mouse spleen cells and exhibited a protective effect in ovalbumin-induced airway inflammation. Our findings indicate that DW2008 effectively inhibits allergic airway inflammatory reactions and airway hyperresponsiveness in a mouse model of asthma, suggesting its potential as an anti-asthmatic agent. |
| doi_str_mv | 10.1248/bpb.b17-00179 |
| format | Article |
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In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregulating pulmonary infiltration of differential inflammatory cells and Th2 cytokines more than a decoction or ethanol extract of J. procumbens did in a mouse asthma model. DW2008 also significantly inhibited airway hyperresponsiveness and reduced the thickness of the airway epithelium. HPLC analysis showed that the major peaks (justicidin A and B) of DW2008 were higher than those of the other extracts. Justicidin A and B significantly suppressed Th2 cytokine levels in mouse spleen cells and exhibited a protective effect in ovalbumin-induced airway inflammation. Our findings indicate that DW2008 effectively inhibits allergic airway inflammatory reactions and airway hyperresponsiveness in a mouse model of asthma, suggesting its potential as an anti-asthmatic agent.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b17-00179</identifier><identifier>PMID: 28867724</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>airway inflammation ; allergy ; Animals ; Anti-Asthmatic Agents - pharmacology ; Anti-Inflammatory Agents - pharmacology ; Asthma ; Asthma - chemically induced ; Asthma - pathology ; Cytokines ; Cytokines - antagonists & inhibitors ; Cytokines - biosynthesis ; Cytokines - metabolism ; Down-Regulation - drug effects ; Epithelium ; Ethanol ; Female ; High-performance liquid chromatography ; Hypersensitivity ; Inflammation ; Justicia procumbens ; justicidin ; Liquid chromatography ; Lung - pathology ; Lymphocytes T ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Respiratory Hypersensitivity - chemically induced ; Respiratory Hypersensitivity - prevention & control ; Respiratory Mucosa - drug effects ; Respiratory Mucosa - pathology ; Respiratory tract ; Respiratory tract diseases ; Rodents ; Spleen ; Spleen - cytology ; Spleen - metabolism ; Splenocytes ; T helper 2 (Th2) cytokine ; Th2 Cells - drug effects ; Th2 Cells - metabolism</subject><ispartof>Biological and Pharmaceutical Bulletin, 2017/09/01, Vol.40(9), pp.1416-1422</ispartof><rights>2017 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-d8b571ae3a7f7b9665d55fdb1d77aa291416af9ef96b51d24e9c9f56a53aeb763</citedby><cites>FETCH-LOGICAL-c702t-d8b571ae3a7f7b9665d55fdb1d77aa291416af9ef96b51d24e9c9f56a53aeb763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28867724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Youm, Jihyun</creatorcontrib><creatorcontrib>Lee, Hyunyong</creatorcontrib><creatorcontrib>Chang, Hwan Bong</creatorcontrib><creatorcontrib>Jeon, Jihyun</creatorcontrib><creatorcontrib>Yoon, Mi Hee</creatorcontrib><creatorcontrib>Woo, Ji Young</creatorcontrib><creatorcontrib>Choi, Min-Soo</creatorcontrib><creatorcontrib>Hwang, Yunha</creatorcontrib><creatorcontrib>Seong, Seungkyoo</creatorcontrib><creatorcontrib>Na, Kyuheum</creatorcontrib><creatorcontrib>Yoon, Joobyoung</creatorcontrib><creatorcontrib>bSchool of Pharmacy</creatorcontrib><creatorcontrib>Sungkyunkwan University</creatorcontrib><creatorcontrib>aResearch Institute</creatorcontrib><creatorcontrib>Dong-Wha Pharmaceutical Company</creatorcontrib><title>Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregulating pulmonary infiltration of differential inflammatory cells and Th2 cytokines more than a decoction or ethanol extract of J. procumbens did in a mouse asthma model. DW2008 also significantly inhibited airway hyperresponsiveness and reduced the thickness of the airway epithelium. HPLC analysis showed that the major peaks (justicidin A and B) of DW2008 were higher than those of the other extracts. Justicidin A and B significantly suppressed Th2 cytokine levels in mouse spleen cells and exhibited a protective effect in ovalbumin-induced airway inflammation. Our findings indicate that DW2008 effectively inhibits allergic airway inflammatory reactions and airway hyperresponsiveness in a mouse model of asthma, suggesting its potential as an anti-asthmatic agent.</description><subject>airway inflammation</subject><subject>allergy</subject><subject>Animals</subject><subject>Anti-Asthmatic Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>Asthma - pathology</subject><subject>Cytokines</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - metabolism</subject><subject>Down-Regulation - drug effects</subject><subject>Epithelium</subject><subject>Ethanol</subject><subject>Female</subject><subject>High-performance liquid chromatography</subject><subject>Hypersensitivity</subject><subject>Inflammation</subject><subject>Justicia procumbens</subject><subject>justicidin</subject><subject>Liquid chromatography</subject><subject>Lung - pathology</subject><subject>Lymphocytes T</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovalbumin</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Respiratory Hypersensitivity - chemically induced</subject><subject>Respiratory Hypersensitivity - prevention & control</subject><subject>Respiratory Mucosa - drug effects</subject><subject>Respiratory Mucosa - pathology</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Rodents</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - metabolism</subject><subject>Splenocytes</subject><subject>T helper 2 (Th2) cytokine</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - metabolism</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkkFv1DAQhSMEokvhyBVZ4lIOKbYTx_FxtZSyqKiHLeJo2c6E9eI4qZ0U9ifxL3F2yyJxGWs0n57f-DnLXhN8SWhZv9eDvtSE5xgTLp5kC1KUPGeUsKfZAgtS5xVh9Vn2IsYdxphjWjzPzmhdV5zTcpH9_jzF0Rqr0BB6M3UafERXv8agzIguPnyjGNfv0AYcmNE-gNujzTQMAWKEiO62FK32Y__D-tRZjzaDA9-b_Zha5Ru07MDZPqi5v31QTk-d9fnaN5OBNLXhp9qjtW-d6jo12t7PIgp96acIqTbgUN-iZRy3nXqZPWuVi_Dq8TzPvn68ult9ym9ur9er5U1u0nJj3tSacaKgULzlWlQVaxhrG00azpWigpSkUq2AVlSakYaWIIxoWaVYoUDzqjjPLo666UHuJ4ij7Gw04JzykHxJIgpWCMoxSejb_9BdPwWf3B2oiuOC00TlR8qEPsYArRyC7VTYS4LlnKFMGcqUoTxkmPg3j6qT7qA50X9DS8D1EUhTa5TrvUsB_LvbRK5t73pJ8UG0xFhITIicd0-FUioYY-WstDoq7eKovsPpKhXSn3BwMFZiKeZyMniamq0KEnzxB8qDx70</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Youm, Jihyun</creator><creator>Lee, Hyunyong</creator><creator>Chang, Hwan Bong</creator><creator>Jeon, Jihyun</creator><creator>Yoon, Mi Hee</creator><creator>Woo, Ji Young</creator><creator>Choi, Min-Soo</creator><creator>Hwang, Yunha</creator><creator>Seong, Seungkyoo</creator><creator>Na, Kyuheum</creator><creator>Yoon, Joobyoung</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma</title><author>Youm, Jihyun ; Lee, Hyunyong ; Chang, Hwan Bong ; Jeon, Jihyun ; Yoon, Mi Hee ; Woo, Ji Young ; Choi, Min-Soo ; Hwang, Yunha ; Seong, Seungkyoo ; Na, Kyuheum ; Yoon, Joobyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-d8b571ae3a7f7b9665d55fdb1d77aa291416af9ef96b51d24e9c9f56a53aeb763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>airway inflammation</topic><topic>allergy</topic><topic>Animals</topic><topic>Anti-Asthmatic Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Asthma</topic><topic>Asthma - chemically induced</topic><topic>Asthma - pathology</topic><topic>Cytokines</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - metabolism</topic><topic>Down-Regulation - drug effects</topic><topic>Epithelium</topic><topic>Ethanol</topic><topic>Female</topic><topic>High-performance liquid chromatography</topic><topic>Hypersensitivity</topic><topic>Inflammation</topic><topic>Justicia procumbens</topic><topic>justicidin</topic><topic>Liquid chromatography</topic><topic>Lung - pathology</topic><topic>Lymphocytes T</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovalbumin</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Respiratory Hypersensitivity - chemically induced</topic><topic>Respiratory Hypersensitivity - prevention & control</topic><topic>Respiratory Mucosa - drug effects</topic><topic>Respiratory Mucosa - pathology</topic><topic>Respiratory tract</topic><topic>Respiratory tract diseases</topic><topic>Rodents</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - metabolism</topic><topic>Splenocytes</topic><topic>T helper 2 (Th2) cytokine</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Youm, Jihyun</creatorcontrib><creatorcontrib>Lee, Hyunyong</creatorcontrib><creatorcontrib>Chang, Hwan Bong</creatorcontrib><creatorcontrib>Jeon, Jihyun</creatorcontrib><creatorcontrib>Yoon, Mi Hee</creatorcontrib><creatorcontrib>Woo, Ji Young</creatorcontrib><creatorcontrib>Choi, Min-Soo</creatorcontrib><creatorcontrib>Hwang, Yunha</creatorcontrib><creatorcontrib>Seong, Seungkyoo</creatorcontrib><creatorcontrib>Na, Kyuheum</creatorcontrib><creatorcontrib>Yoon, Joobyoung</creatorcontrib><creatorcontrib>bSchool of Pharmacy</creatorcontrib><creatorcontrib>Sungkyunkwan University</creatorcontrib><creatorcontrib>aResearch Institute</creatorcontrib><creatorcontrib>Dong-Wha Pharmaceutical Company</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Youm, Jihyun</au><au>Lee, Hyunyong</au><au>Chang, Hwan Bong</au><au>Jeon, Jihyun</au><au>Yoon, Mi Hee</au><au>Woo, Ji Young</au><au>Choi, Min-Soo</au><au>Hwang, Yunha</au><au>Seong, Seungkyoo</au><au>Na, Kyuheum</au><au>Yoon, Joobyoung</au><aucorp>bSchool of Pharmacy</aucorp><aucorp>Sungkyunkwan University</aucorp><aucorp>aResearch Institute</aucorp><aucorp>Dong-Wha Pharmaceutical Company</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2017</date><risdate>2017</risdate><volume>40</volume><issue>9</issue><spage>1416</spage><epage>1422</epage><pages>1416-1422</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by downregulating pulmonary infiltration of differential inflammatory cells and Th2 cytokines more than a decoction or ethanol extract of J. procumbens did in a mouse asthma model. DW2008 also significantly inhibited airway hyperresponsiveness and reduced the thickness of the airway epithelium. HPLC analysis showed that the major peaks (justicidin A and B) of DW2008 were higher than those of the other extracts. Justicidin A and B significantly suppressed Th2 cytokine levels in mouse spleen cells and exhibited a protective effect in ovalbumin-induced airway inflammation. Our findings indicate that DW2008 effectively inhibits allergic airway inflammatory reactions and airway hyperresponsiveness in a mouse model of asthma, suggesting its potential as an anti-asthmatic agent.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>28867724</pmid><doi>10.1248/bpb.b17-00179</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | airway inflammation allergy Animals Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - pharmacology Asthma Asthma - chemically induced Asthma - pathology Cytokines Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytokines - metabolism Down-Regulation - drug effects Epithelium Ethanol Female High-performance liquid chromatography Hypersensitivity Inflammation Justicia procumbens justicidin Liquid chromatography Lung - pathology Lymphocytes T Mice Mice, Inbred BALB C Ovalbumin Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - prevention & control Respiratory Mucosa - drug effects Respiratory Mucosa - pathology Respiratory tract Respiratory tract diseases Rodents Spleen Spleen - cytology Spleen - metabolism Splenocytes T helper 2 (Th2) cytokine Th2 Cells - drug effects Th2 Cells - metabolism |
| title | Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma |
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