FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells

Epithelial-to-mesenchymal transition (EMT) is an important process during embryonic development and tumor progression by which adherent epithelial cells acquire mesenchymal properties. Forkhead box protein A1 (FOXA1) is a transcriptional regulator preferentially expressed in epithelial breast cancer...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/09/01, Vol.40(9), pp.1483-1489
Hauptverfasser:	Anzai, Erina, Hirata, Kensuke, Shibazaki, Misato, Yamada, Chiaki, Morii, Mariko, Honda, Takuya, Yamaguchi, Naoto, Yamaguchi, Noritaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cadherins - biosynthesis Cadherins - drug effects E-cadherin Embryogenesis Embryonic growth stage Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects epithelial–mesenchymal transition estrogen receptor Estrogen Receptor alpha - drug effects Estrogen Receptor alpha - metabolism Female forkhead box protein A1 Forkhead protein Gene expression Gene Knockdown Techniques Hepatocyte Nuclear Factor 3-alpha - genetics Hepatocyte Nuclear Factor 3-alpha - pharmacology Humans MCF-7 Cells Mesenchyme Plasmids - genetics Protein expression Protein Processing, Post-Translational - drug effects Proteins RNA, Messenger - biosynthesis Slug Snail Family Transcription Factors - antagonists & inhibitors Snail Family Transcription Factors - biosynthesis Snail Family Transcription Factors - genetics Transcription
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