Modeling of the burst release from PLGA micro- and nanoparticles as function of physicochemical parameters and formulation characteristics

[Display omitted] A substantial drug release from poly(lactic-co-glycolic) acid (PLGA) micro- and nanoparticles can occur in the first hours of immersion, which is referred to as burst release. A strong burst release (when not intentional) is to be avoided as it decreases the efficacy of the treatme...

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Veröffentlicht in:	International journal of pharmaceutics 2017-10, Vol.532 (1), p.229-240
Hauptverfasser:	Rodrigues de Azevedo, Cristiana, von Stosch, Moritz, Costa, Mariana S., Ramos, A.M., Cardoso, M. Margarida, Danhier, Fabienne, Préat, Véronique, Oliveira, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Burst release Controlled drug release Decision trees Drug Compounding Drug Liberation Lactic Acid - chemistry Models, Theoretical Nanoparticles - chemistry Partial least squares Pharmaceutical Preparations - chemistry PLGA carriers Polyglycolic Acid - chemistry Regression Analysis
Online-Zugang:	Volltext
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