Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines

Kevin Yip and colleagues report a method for determining the target genes of enhancers in specific cells and tissues by combining global trends across many samples with sample-specific information, and considering the joint effect of multiple enhancers. They apply their method to reconstruct enhance...

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Veröffentlicht in:	Nature genetics 2017-10, Vol.49 (10), p.1428-1436
Hauptverfasser:	Cao, Qin, Anyansi, Christine, Hu, Xihao, Xu, Liangliang, Xiong, Lei, Tang, Wenshu, Mok, Myth T S, Cheng, Chao, Fan, Xiaodan, Gerstein, Mark, Cheng, Alfred S L, Yip, Kevin Y
Format:	Artikel
Sprache:	eng
Schlagworte:	38/88 45/70 631/114 631/337/176 Agriculture analysis Animal Genetics and Genomics Bioinformatics Biomedicine Biotechnology Cancer Research Carcinoma, Hepatocellular - genetics Cell Line Deoxyribonucleic acid DNA DNA Methylation Enhancer Elements, Genetic Enhancers Epigenesis, Genetic Gene expression Gene Expression Regulation Gene Function Gene regulation Gene Regulatory Networks - genetics Genes Genes, Neoplasm Genetic research Genomes Hepatocellular carcinoma Human Genetics Humans Identification and classification K562 Cells Liver cancer Liver Neoplasms - genetics Methods Mutation Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Networks Phosphoproteins - biosynthesis Phosphoproteins - genetics Primary Cell Culture Proteins RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics Telomerase - biosynthesis Telomerase - genetics Thyroid gland Transcription (Genetics) Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Trends
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