Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non–small-cell Lung Cancer

A higher T790M detection rate is desirable for introducing third-generation epidermal growth factor receptor-tyrosine kinase inhibitor treatment. This study evaluated the clinical factors influencing the incidence of T790M. Postsurgery recurrence and longer total duration of epidermal growth factor...

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Veröffentlicht in:	Clinical lung cancer 2018-03, Vol.19 (2), p.e247-e252
Hauptverfasser:	Kawamura, Takahisa, Kenmotsu, Hirotsugu, Omori, Shota, Nakashima, Kazuhisa, Wakuda, Kazushige, Ono, Akira, Naito, Tateaki, Murakami, Haruyasu, Omae, Katsuhiro, Mori, Keita, Tanigawara, Yusuke, Nakajima, Takashi, Ohde, Yasuhisa, Endo, Masahiro, Takahashi, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired resistance Aged Antineoplastic Agents - therapeutic use Biopsy Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Disease progression Drug Resistance, Neoplasm EGFR-TKI Epidermal growth factor receptor ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - surgery Male Middle Aged Mutation Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Predictive marker Prognosis Protein Kinase Inhibitors - therapeutic use Retrospective Studies Time Factors
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