MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases

Recent progress in dissecting the molecular paracrine circuits of cancer and stromal cells in bone metastases (BM) are offering new options to improve current merely palliative approach. The study of tumor-stroma metabolic interplay may further ameliorate this scenario. In this context, we demonstra...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2017-12, Vol.1863 (12), p.3254-3264
Hauptverfasser:	Lemma, Silvia, Di Pompo, Gemma, Porporato, Paolo E., Sboarina, Martina, Russell, Shonagh, Gillies, Robert J., Baldini, Nicola, Sonveaux, Pierre, Avnet, Sofia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone metastases Bone Neoplasms - metabolism Bone Neoplasms - secondary Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor - metabolism Coumarins - antagonists & inhibitors Female Glucose - metabolism Glycolysis Humans Lactate Lactates - metabolism MCF-7 Cells Mice Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism Osteoclast Osteoclasts - metabolism Osteoclasts - pathology Stromal Cells - metabolism Stromal Cells - pathology Symporters - metabolism Tumor metabolism
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