Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning

Oximes K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were tested as pretreatment drugs in tabun-poisoned mice followed by treatment with atropine plus K033, K048, K027 [1-(4-hydroxyiminomethylp...

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Veröffentlicht in:	Toxicology (Amsterdam) 2006-11, Vol.228 (1), p.41-50
Hauptverfasser:	Lucić Vrdoljak, Ana, Čalić, Maja, Radić, Božica, Berend, Suzana, Jun, Daniel, Kuča, Kamil, Kovarik, Zrinka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - drug effects Animals Antidote Antidotes - pharmacology Atropine - pharmacology Biological and medical sciences Bioscavenger Butyrylcholinesterase Butyrylcholinesterase - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - poisoning Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Antagonism Drug Therapy, Combination Erythrocytes - enzymology Gas, fumes Humans Lethal Dose 50 Male Medical sciences Mice Mice, Inbred BALB C Nerve agents Organophosphate Poisoning Organophosphates Oxime Oximes - pharmacology Poisoning - prevention & control Pretreatment Pyridinium Compounds - pharmacology Tabun Toxicology
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