Species selective resistance of cardiac muscle voltage gated sodium channels: Characterization of brevetoxin and ciguatoxin binding sites in rats and fish

Brevetoxins (PbTxs) and ciguatoxins (CTXs) are two suites of dinoflagellate derived marine polyether neurotoxins that target the voltage gated sodium channel (VGSC). PbTxs are commonly responsible for massive fish kills and unusual mortalities in marine mammals. CTXs, more often noted for human into...

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Veröffentlicht in:	Toxicon (Oxford) 2006-11, Vol.48 (6), p.702-712
Hauptverfasser:	Bottein Dechraoui, Marie-Yasmine, Wacksman, Jeremy J., Ramsdell, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bass - metabolism Biological and medical sciences Brain - cytology Brain - metabolism Brevetoxin Centropristis striata Ciguatera Ciguatoxin Ciguatoxins - chemistry Ciguatoxins - metabolism Ciguatoxins - pharmacology Dinoflagellida - metabolism Fish Proteins - chemistry Fish Proteins - drug effects Fish Proteins - metabolism Isoform Mammals Marine Marine toxins Marine Toxins - chemistry Marine Toxins - metabolism Marine Toxins - pharmacology Medical sciences Muscle Fibers, Skeletal - metabolism Myocytes, Cardiac - chemistry Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Neurotoxins - chemistry Neurotoxins - metabolism Neurotoxins - pharmacology Oxocins - chemistry Oxocins - metabolism Oxocins - pharmacology Plant poisons toxicology Rats Sodium Channels - chemistry Sodium Channels - drug effects Sodium Channels - metabolism Species Specificity Teleost fish Teleostei Toxicology Voltage gated sodium channel
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