Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

Recent studies have reported that smokers tend to be less susceptible to Parkinson’s disease (PD) and the stimulation of nicotinic acetylcholine receptor (nAChR) is considered to confer a neuroprotective effect. Galantamine is an acetylcholinesterase inhibitor and an allosteric potentiating ligand f...

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Veröffentlicht in:	Neuroscience research 2008-12, Vol.62 (4), p.254-261
Hauptverfasser:	Yanagida, Takashi, Takeuchi, Hiroki, Kitamura, Yoshihisa, Takata, Kazuyuki, Minamino, Hideaki, Shibaike, Tomonori, Tsushima, Jun, Kishimoto, Koji, Yasui, Hiroyuki, Taniguchi, Takashi, Shimohama, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Allosteric potentiating ligand alpha7 Nicotinic Acetylcholine Receptor Animals Disease Models, Animal Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Synergism Electron Spin Resonance Spectroscopy - methods Functional Laterality Galantamine Galantamine - therapeutic use Gene Expression Regulation - drug effects Male Mecamylamine - pharmacology Methamphetamine - pharmacology Motor Activity - drug effects Neuroprotective Agents - therapeutic use Nicotine - therapeutic use Nicotinic acetylcholine receptor Nicotinic Antagonists - pharmacology Parkinsonian Disorders - drug therapy Parkinsonian Disorders - etiology Parkinsonian Disorders - metabolism Parkinson’s disease Rats Rats, Wistar Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism RNA, Messenger - metabolism Rotarod Performance Test Tyrosine 3-Monooxygenase - metabolism
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